Detailed information of TA system TA054743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3594211..3594863
• Replicon: chromosome
• Accession: NZ_CP011642
• Organism: Serratia marcescens strain CAV1492

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: AB188_RS18660
• Protein ID: WP_038878669.1
• Coordinates: 3594519..3594863 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GZD7
• Locus tag: AB188_RS18655
• Protein ID: WP_038878665.1
• Coordinates: 3594211..3594513 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB188_RS18630	3589219..3589866	-	648	WP_047729966.1	DsbA family protein	-
AB188_RS18635	3589935..3590819	-	885	WP_033635778.1	MBL fold metallo-hydrolase	-
AB188_RS18640	3590928..3591836	+	909	WP_015378928.1	LysR family transcriptional regulator	-
AB188_RS18645	3591864..3592787	-	924	WP_047729967.1	LysR family transcriptional regulator	-
AB188_RS18650	3592921..3594183	+	1263	WP_038878662.1	diaminopimelate decarboxylase	-
AB188_RS18655	3594211..3594513	-	303	WP_038878665.1	helix-turn-helix transcriptional regulator	Antitoxin
AB188_RS18660	3594519..3594863	-	345	WP_038878669.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AB188_RS18665	3595023..3596042	-	1020	WP_038878671.1	HTH-type transcriptional regulator GalR	-
AB188_RS18670	3596263..3598521	+	2259	WP_038878674.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
AB188_RS29755	3598522..3598707	+	186	WP_038878678.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13367.40 Da
• Isoelectric Point: 10.6629

>T54743 WP_038878669.1 NZ_CP011642:c3594863-3594519 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDQRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T54743 NZ_CP011642:c3594863-3594519 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAATTGGCACGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCATTCAACATCGCGGGCGCCCTTTCAGGGTATTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACCAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11111.04 Da
• Isoelectric Point: 10.3986

>AT54743 WP_038878665.1 NZ_CP011642:c3594513-3594211 [Serratia marcescens]
MAKPLSQLIDKLDPAVVATARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT54743 NZ_CP011642:c3594513-3594211 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCACAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAACTGTCATCGCTCAAACGCTATATCGAGGCGATG
GGTGGCACGCTATCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GZD7