Detailed information of TA system TA054741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 2544196..2544797
• Replicon: chromosome
• Accession: NZ_CP011642
• Organism: Serratia marcescens strain CAV1492

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: AB188_RS13855
• Protein ID: WP_033636540.1
• Coordinates: 2544417..2544797 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0G3SPC0
• Locus tag: AB188_RS13850
• Protein ID: WP_038875999.1
• Coordinates: 2544196..2544417 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB188_RS13835	2539345..2540322	+	978	WP_016929588.1	glyoxylate/hydroxypyruvate reductase GhrB	-
AB188_RS29745	2540324..2540476	-	153	WP_168166338.1	hypothetical protein	-
AB188_RS13840	2540672..2542735	+	2064	WP_047729571.1	alpha-amylase	-
AB188_RS13845	2542871..2544121	+	1251	WP_004933935.1	valine--pyruvate transaminase	-
AB188_RS13850	2544196..2544417	+	222	WP_038875999.1	ribbon-helix-helix domain-containing protein	Antitoxin
AB188_RS13855	2544417..2544797	+	381	WP_033636540.1	type II toxin-antitoxin system VapC family toxin	Toxin
AB188_RS13860	2544808..2546466	-	1659	WP_047729572.1	putative transporter	-
AB188_RS13865	2546634..2547062	-	429	WP_004933922.1	heat shock chaperone IbpB	-
AB188_RS13870	2547163..2547576	-	414	WP_004933919.1	heat shock chaperone IbpA	-
AB188_RS13875	2547886..2548233	+	348	WP_016929593.1	YceK/YidQ family lipoprotein	-
AB188_RS13880	2548264..2549544	-	1281	WP_047729573.1	DUF3748 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-102)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14185.53 Da
• Isoelectric Point: 7.3170

>T54741 WP_033636540.1 NZ_CP011642:2544417-2544797 [Serratia marcescens]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Nucleotide

• Length: 381 bp

>T54741 NZ_CP011642:2544417-2544797 [Serratia marcescens]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8563.50 Da
• Isoelectric Point: 4.4791

>AT54741 WP_038875999.1 NZ_CP011642:2544196-2544417 [Serratia marcescens]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Nucleotide

• Length: 222 bp

>AT54741 NZ_CP011642:2544196-2544417 [Serratia marcescens]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGGCGGAGAACCACGTTGAAGATCCCAGCAATGCCTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A0G3SPC0