Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2502026..2502561 Replicon chromosome
Accession NZ_CP011642
Organism Serratia marcescens strain CAV1492

Toxin (Protein)


Gene name relE Uniprot ID A0A854J4R0
Locus tag AB188_RS13665 Protein ID WP_038875945.1
Coordinates 2502026..2502301 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A255NGR4
Locus tag AB188_RS13670 Protein ID WP_047729547.1
Coordinates 2502301..2502561 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AB188_RS13645 2497844..2498836 - 993 WP_047729540.1 acyltransferase -
AB188_RS13650 2499054..2500301 + 1248 WP_038875940.1 MFS transporter -
AB188_RS13655 2500355..2500981 - 627 WP_047729542.1 LysE family translocator -
AB188_RS13660 2501103..2502014 + 912 WP_047729544.1 LysR family transcriptional regulator -
AB188_RS13665 2502026..2502301 - 276 WP_038875945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AB188_RS13670 2502301..2502561 - 261 WP_047729547.1 ribbon-helix-helix domain-containing protein Antitoxin
AB188_RS13675 2502644..2504485 - 1842 WP_047729548.1 selenocysteine-specific translation elongation factor -
AB188_RS13680 2504482..2505876 - 1395 WP_047729550.1 L-seryl-tRNA(Sec) selenium transferase -
AB188_RS13685 2505944..2506549 - 606 WP_047729552.1 glutathione S-transferase -
AB188_RS13690 2506590..2507240 - 651 WP_047729554.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.34 Da        Isoelectric Point: 10.6099

>T54740 WP_038875945.1 NZ_CP011642:c2502301-2502026 [Serratia marcescens]
MALKWTSKALSDLARLFEFLALANRTVAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T54740 NZ_CP011642:c2502301-2502026 [Serratia marcescens]
ATGGCGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGCTAACCGCACTGT
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATCCTCGCCTGGGTGAAAGACTGGATG
AGTTTTTACCGCAGGAAGTGAGACGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9696.04 Da        Isoelectric Point: 4.5201

>AT54740 WP_047729547.1 NZ_CP011642:c2502561-2502301 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALVDVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT54740 NZ_CP011642:c2502561-2502301 [Serratia marcescens]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGAACG
TTCACGGGGATGGATAGTGAAACAAGCCCTCGCCGCCTGGCTCGAGCAAGAGGAAGAGCGCCGTCGGTTAACGCTGGCGG
CGTTGGTCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854J4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A255NGR4

References