Detailed information of TA system TA054738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2364212..2364684
• Replicon: chromosome
• Accession: NZ_CP011642
• Organism: Serratia marcescens strain CAV1492

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A255N1I8
• Locus tag: AB188_RS13030
• Protein ID: WP_047729413.1
• Coordinates: 2364212..2364487 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: AB188_RS13035
• Protein ID: WP_033649649.1
• Coordinates: 2364487..2364684 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB188_RS13015	2359255..2359632	-	378	WP_047729408.1	AprI/Inh family metalloprotease inhibitor	-
AB188_RS13020	2359688..2361151	-	1464	WP_038874135.1	serralysin family metalloprotease	-
AB188_RS13025	2361834..2364152	+	2319	WP_047729411.1	zinc/cadmium/mercury/lead-transporting ATPase	-
AB188_RS13030	2364212..2364487	-	276	WP_047729413.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
AB188_RS13035	2364487..2364684	-	198	WP_033649649.1	hypothetical protein	Antitoxin
AB188_RS13040	2364746..2364991	-	246	WP_025304890.1	sulfurtransferase TusA	-
AB188_RS13045	2365212..2365871	+	660	WP_047729415.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
AB188_RS13050	2365923..2366357	+	435	WP_047729416.1	GNAT family N-acetyltransferase	-
AB188_RS13055	2366438..2367001	+	564	WP_047729417.1	DcrB family lipoprotein	-
AB188_RS13060	2367037..2368236	-	1200	WP_047729419.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
AB188_RS13065	2368233..2369501	-	1269	WP_047729421.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10694.62 Da
• Isoelectric Point: 11.2806

>T54738 WP_047729413.1 NZ_CP011642:c2364487-2364212 [Serratia marcescens]
MLNIEWTRVARQDLGEIVGFIANDNPLAARKMKVLIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T54738 NZ_CP011642:c2364487-2364212 [Serratia marcescens]
ATGCTCAACATCGAATGGACTCGAGTCGCACGTCAGGATCTGGGGGAGATTGTGGGATTTATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGTTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTGCATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7398.49 Da
• Isoelectric Point: 4.4143

>AT54738 WP_033649649.1 NZ_CP011642:c2364684-2364487 [Serratia marcescens]
MSILLLPTVAKMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Nucleotide

• Length: 198 bp

>AT54738 NZ_CP011642:c2364684-2364487 [Serratia marcescens]
ATGAGTATTTTACTGCTGCCTACGGTTGCCAAGATGGAAAATGAGGAGCGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCACGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Structures

Toxin

• AlphaFold DB: A0A255N1I8