Detailed information of TA system TA054734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 746951..747546
• Replicon: chromosome
• Accession: NZ_CP011642
• Organism: Serratia marcescens strain CAV1492

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: AB188_RS28135
• Protein ID: WP_071605322.1
• Coordinates: 747292..747546 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: AB188_RS05405
• Protein ID: WP_033633573.1
• Coordinates: 746951..747292 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AB188_RS28130	743292..743507	-	216	WP_071845399.1	ogr/Delta-like zinc finger family protein	-
AB188_RS05390	743458..744566	+	1109	Protein_712	oxidoreductase	-
AB188_RS05395	744566..745588	+	1023	WP_047728002.1	phage portal protein	-
AB188_RS05400	745626..746831	-	1206	WP_071845277.1	ISL3 family transposase	-
AB188_RS05405	746951..747292	-	342	WP_033633573.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
AB188_RS28135	747292..747546	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
AB188_RS05410	748200..748901	-	702	WP_038881175.1	hypothetical protein	-
AB188_RS29325	749058..749318	+	261	WP_139145145.1	hypothetical protein	-
AB188_RS05420	749351..749575	-	225	WP_047728004.1	hypothetical protein	-
AB188_RS05425	749614..750589	-	976	Protein_720	replication endonuclease	-
AB188_RS05430	750757..751500	-	744	WP_047728005.1	ankyrin repeat domain-containing protein	-
AB188_RS05435	751590..752363	-	774	WP_038881165.1	ankyrin repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T54734 WP_071605322.1 NZ_CP011642:c747546-747292 [Serratia marcescens]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T54734 NZ_CP011642:c747546-747292 [Serratia marcescens]
ATGAACAAACGACACCAAAAAACGCTGTCAGATGTGTTTGCCCGGCCTGTCAACGGTTCTATAAAGTGGTCTGATATTGA
GGCGCTTTTTACCGCATTAGGGGCGGAGATTCACGAAAGGGAAGGTTCTAGGATCGCGGTGCTGTTGAAAGGTGAAAAAA
GAGTCTTTCACCGGCCACACCCCAGACCTACCACTGACAAGGGGGCGGTTAACTCTATTCGGATCTGGTTGGATAGCTTA
GGAATAAAACCATGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12399.90 Da
• Isoelectric Point: 4.5789

>AT54734 WP_033633573.1 NZ_CP011642:c747292-746951 [Serratia marcescens]
MNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLSP
ERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 342 bp

>AT54734 NZ_CP011642:c747292-746951 [Serratia marcescens]
ATGAATAACACACTGAAAATTGACGGCCATACGGCCGTCATCAACTTCGACCCAGAAATTGAAATGTTCCGGGGCGAGTT
TGTCGGGCTGAACGGTGGCGCCGACTTCTACGCCTACAGCGTGGACGAGCTGAAGAAAGAAGGCGCGATCTCACTCGCGG
TCTTTCTCGATGAGTGCCATAAAGACGGCATCGAGCCTTACAAGTCGTACAGCGGCAAAGTAACCACCCGCCTGTCGCCG
GAACGCCATCAGGCGTTAGCCATTGCCGCTCAGGCCACCGGGCAGTCGATTAATGAACTGCTGAATGAAGGTGTTGATCT
GGTTATCGAAAAGCATTCCTGA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1