Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 875208..875832 Replicon chromosome
Accession NZ_CP011486
Organism Helicobacter pylori strain K26A1

Toxin (Protein)


Gene name relE Uniprot ID A0A1A9HEH6
Locus tag AA977_RS04145 Protein ID WP_064434698.1
Coordinates 875208..875474 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1A9HF01
Locus tag AA977_RS04150 Protein ID WP_064434699.1
Coordinates 875461..875832 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA977_RS04120 871014..871781 - 768 WP_033617843.1 ABC transporter ATP-binding protein -
AA977_RS04125 871781..872761 - 981 WP_064434695.1 iron ABC transporter permease -
AA977_RS04130 872761..873609 - 849 WP_064434696.1 SDR family oxidoreductase -
AA977_RS04135 873749..874273 + 525 WP_001135601.1 acyl-CoA thioesterase -
AA977_RS07605 874645..874858 - 214 Protein_812 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
AA977_RS04140 874872..875162 - 291 WP_064434697.1 hypothetical protein -
AA977_RS04145 875208..875474 - 267 WP_064434698.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AA977_RS04150 875461..875832 - 372 WP_064434699.1 hypothetical protein Antitoxin
AA977_RS07830 876002..877267 - 1266 Protein_816 hypothetical protein -
AA977_RS04160 877267..877532 - 266 Protein_817 type II toxin-antitoxin system YafQ family toxin -
AA977_RS04165 877519..877882 - 364 Protein_818 hypothetical protein -
AA977_RS07955 878140..878796 - 657 WP_172795994.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10409.45 Da        Isoelectric Point: 9.9603

>T54295 WP_064434698.1 NZ_CP011486:c875474-875208 [Helicobacter pylori]
MLKIKHHILYKKDFKKLVKNGFDDSVLNEVILALRKKESLPPQFKDHALKGVWKPYRECHIKADILLIYLIKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T54295 NZ_CP011486:c875474-875208 [Helicobacter pylori]
ATGCTGAAAATTAAGCACCATATCCTTTATAAAAAAGATTTTAAAAAACTTGTTAAAAATGGGTTTGATGATAGCGTTTT
GAATGAAGTTATCCTAGCTCTAAGAAAAAAAGAGTCGCTACCCCCCCAATTTAAAGATCATGCTTTAAAGGGAGTTTGGA
AGCCTTATAGAGAATGCCACATTAAAGCTGATATTTTGCTTATTTATTTGATCAAAGATGATGAGCTTATTTTATTAAGA
CTAGGCAGTCATAGCGAGTTGTTTTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 14423.36 Da        Isoelectric Point: 5.9894

>AT54295 WP_064434699.1 NZ_CP011486:c875832-875461 [Helicobacter pylori]
MPNTTAKKDYTKYSEKQLFNLINKLEQKIKKMQEDRLFFKEKMAKELEKRDKNFKDKLDAANELLQKISQAFGDKKDCCF
GHETPNLETQQAMREALNGENLEAIEDFSAWANEIKKEVNAEN

Download         Length: 372 bp

>AT54295 NZ_CP011486:c875832-875461 [Helicobacter pylori]
ATGCCCAACACCACTGCCAAAAAAGATTACACTAAATACAGCGAAAAACAGCTTTTTAACTTGATCAACAAATTAGAACA
AAAAATCAAAAAAATGCAAGAGGATAGGCTTTTTTTCAAAGAAAAAATGGCTAAAGAATTAGAAAAAAGAGACAAAAACT
TTAAGGATAAGTTGGACGCAGCCAATGAGCTTTTGCAAAAAATCAGCCAAGCTTTTGGTGATAAAAAAGATTGTTGTTTT
GGGCATGAAACCCCAAACCTTGAAACGCAACAAGCCATGAGAGAAGCGTTAAATGGTGAAAACTTAGAAGCTATTGAAGA
CTTTTCTGCATGGGCAAATGAAATCAAAAAGGAAGTGAATGCTGAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1A9HEH6

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9HF01

References