Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 22045..22580 Replicon plasmid pCFSAN029787_02
Accession NZ_CP011418
Organism Escherichia coli strain CFSAN029787

Toxin (Protein)


Gene name relE Uniprot ID A0A0M1UJC2
Locus tag AA102_RS26920 Protein ID WP_001270422.1
Coordinates 22293..22580 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID L4J0V6
Locus tag AA102_RS26915 Protein ID WP_001132895.1
Coordinates 22045..22296 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AA102_RS30365 17062..17373 - 312 WP_001309256.1 hypothetical protein -
AA102_RS31435 17437..17796 - 360 WP_001336695.1 DUF1281 domain-containing protein -
AA102_RS31010 17803..17946 - 144 WP_000270807.1 DUF1281 domain-containing protein -
AA102_RS29415 18113..18889 - 777 Protein_18 hypothetical protein -
AA102_RS26900 19123..20085 - 963 WP_000756328.1 ParB/RepB/Spo0J family partition protein -
AA102_RS26905 20082..21287 - 1206 WP_000817635.1 AAA family ATPase -
AA102_RS26915 22045..22296 + 252 WP_001132895.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
AA102_RS26920 22293..22580 + 288 WP_001270422.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AA102_RS29425 22582..22993 + 412 Protein_23 DDE-type integrase/transposase/recombinase -
AA102_RS26935 23637..24614 + 978 WP_001309253.1 RepB family plasmid replication initiator protein -
AA102_RS26940 24857..25597 - 741 WP_001066947.1 tyrosine-type recombinase/integrase -
AA102_RS26945 25718..25906 - 189 WP_001332784.1 hypothetical protein -
AA102_RS26950 26273..27442 + 1170 WP_001072358.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 / aph(3'')-Ib / aph(6)-Id - 1..47606 47606


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11262.30 Da        Isoelectric Point: 10.4703

>T54229 WP_001270422.1 NZ_CP011418:22293-22580 [Escherichia coli]
MRYQVKFREDALKEWQKMDKTIQQQFAKKLKKCCDNPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDEQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T54229 NZ_CP011418:22293-22580 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9178.47 Da        Isoelectric Point: 4.2108

>AT54229 WP_001132895.1 NZ_CP011418:22045-22296 [Escherichia coli]
MPNIILSDTSASVSELKKNPMATVSAGDGFPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLVAERSNQPLHDVDLD
KYL

Download         Length: 252 bp

>AT54229 NZ_CP011418:22045-22296 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M1UJC2

Antitoxin

Source ID Structure
AlphaFold DB L4J0V6

References