Detailed information of TA system TA053772

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3615697..3616369
• Replicon: chromosome
• Accession: NZ_CP011286
• Organism: Yersinia enterocolitica strain KNG22703

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7U7FIQ4
• Locus tag: XM56_RS16250
• Protein ID: WP_005166047.1
• Coordinates: 3615697..3616122 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: XM56_RS16255
• Protein ID: WP_013649338.1
• Coordinates: 3616103..3616369 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XM56_RS16230	3611471..3611989	+	519	WP_005166042.1	flavodoxin FldB	-
XM56_RS16235	3612048..3613469	-	1422	WP_013649341.1	cell envelope integrity protein CreD	-
XM56_RS16240	3613561..3614988	-	1428	WP_032904346.1	two-component system sensor histidine kinase CreC	-
XM56_RS16245	3614999..3615697	-	699	WP_005166045.1	two-component system response regulator CreB	-
XM56_RS16250	3615697..3616122	-	426	WP_005166047.1	protein YgfX	Toxin
XM56_RS16255	3616103..3616369	-	267	WP_013649338.1	FAD assembly factor SdhE	Antitoxin
XM56_RS16260	3616636..3617628	+	993	WP_005166051.1	tRNA-modifying protein YgfZ	-
XM56_RS16265	3617824..3618843	+	1020	WP_020282800.1	IS110 family transposase	-
XM56_RS16270	3619255..3619938	-	684	WP_013649336.1	hemolysin III family protein	-
XM56_RS16275	3620169..3620771	+	603	WP_013649335.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3617824..3618843	1019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16425.21 Da
• Isoelectric Point: 9.8217

>T53772 WP_005166047.1 NZ_CP011286:c3616122-3615697 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Nucleotide

• Length: 426 bp

>T53772 NZ_CP011286:c3616122-3615697 [Yersinia enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCACTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10519.06 Da
• Isoelectric Point: 5.1405

>AT53772 WP_013649338.1 NZ_CP011286:c3616369-3616103 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KVRGPVAM

Nucleotide

• Length: 267 bp

>AT53772 NZ_CP011286:c3616369-3616103 [Yersinia enterocolitica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGTCCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A7U7FIQ4