Detailed information of TA system TA053761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 1879205..1879750
• Replicon: chromosome
• Accession: NZ_CP011286
• Organism: Yersinia enterocolitica strain KNG22703

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: XM56_RS08385
• Protein ID: WP_013649743.1
• Coordinates: 1879472..1879750 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A0A7T9Y052
• Locus tag: XM56_RS08380
• Protein ID: WP_005161466.1
• Coordinates: 1879205..1879465 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XM56_RS08350	1874366..1875541	-	1176	WP_013649737.1	phage tail sheath protein	-
XM56_RS08355	1875851..1876036	-	186	WP_013649738.1	hypothetical protein	-
XM56_RS22105	1876170..1876308	-	139	Protein_1634	ash family protein	-
XM56_RS08360	1876600..1877484	-	885	WP_072077075.1	Rpn family recombination-promoting nuclease/putative transposase	-
XM56_RS22540	1877690..1877866	-	177	WP_013649740.1	hypothetical protein	-
XM56_RS08365	1878308..1878628	-	321	WP_013649741.1	hypothetical protein	-
XM56_RS08370	1878618..1878824	-	207	WP_013649742.1	hypothetical protein	-
XM56_RS08375	1878966..1879133	+	168	WP_005161469.1	hypothetical protein	-
XM56_RS08380	1879205..1879465	+	261	WP_005161466.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
XM56_RS08385	1879472..1879750	+	279	WP_013649743.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
XM56_RS21260	1879803..1880415	-	613	Protein_1642	tail fiber assembly protein	-
XM56_RS08400	1880415..1881707	-	1293	WP_013649744.1	phage tail protein	-
XM56_RS22545	1881680..1881961	-	282	WP_013649745.1	phage tail protein	-
XM56_RS08410	1881954..1882499	-	546	WP_032904715.1	phage tail protein I	-
XM56_RS08415	1882492..1883400	-	909	WP_013649747.1	baseplate assembly protein	-
XM56_RS08420	1883400..1883756	-	357	WP_005161449.1	GPW/gp25 family protein	-
XM56_RS08425	1883753..1884388	-	636	WP_013649748.1	phage baseplate assembly protein V	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	pilW	1867742..1911006	43264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10930.63 Da
• Isoelectric Point: 9.8470

>T53761 WP_013649743.1 NZ_CP011286:1879472-1879750 [Yersinia enterocolitica]
MTKQREIEYSGQFQKDVKKAQKRHKDINKLKTIMALLIDDKLPLPVIYKDHQLQGNYKGYRDAHIEPDWLIIYKITDDLL
RFGRTGSHSDLF

Nucleotide

• Length: 279 bp

>T53761 NZ_CP011286:1879472-1879750 [Yersinia enterocolitica]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
AAATAAACTTAAAACTATTATGGCGCTGCTAATTGACGATAAATTACCCTTGCCTGTTATATACAAGGATCATCAATTAC
AAGGTAATTACAAAGGTTACAGGGATGCGCATATAGAGCCAGACTGGCTTATCATCTACAAGATTACTGATGATTTGCTT
CGCTTCGGAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9277.75 Da
• Isoelectric Point: 7.0134

>AT53761 WP_005161466.1 NZ_CP011286:1879205-1879465 [Yersinia enterocolitica]
MAANAFVRARIDETLKNEAAAVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNELTAKTIANSEKGVDVHKAKDADDL
FDKLGI

Nucleotide

• Length: 261 bp

>AT53761 NZ_CP011286:1879205-1879465 [Yersinia enterocolitica]
ATGGCTGCAAATGCTTTTGTTCGTGCTCGTATAGATGAAACCCTAAAAAATGAAGCCGCTGCTGTGCTTGCTGGCATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTCGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAACTTACCGCTAAAACTATTGCCAACAGCGAGAAAGGTGTCGATGTCCACAAAGCAAAGGATGCCGATGATCTG
TTTGATAAATTAGGTATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A7T9Y052