Detailed information of TA system TA053757

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 104924..105508
• Replicon: chromosome
• Accession: NZ_CP011286
• Organism: Yersinia enterocolitica strain KNG22703

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: A0A7U7ISC5
• Locus tag: XM56_RS00400
• Protein ID: WP_005165296.1
• Coordinates: 104924..105292 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: XM56_RS20945
• Protein ID: WP_129019424.1
• Coordinates: 105356..105508 (-)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XM56_RS00385	100756..101229	-	474	WP_032904420.1	GNAT family N-acetyltransferase	-
XM56_RS00390	102779..103798	-	1020	WP_020282800.1	IS110 family transposase	-
XM56_RS00395	103835..104695	-	861	WP_013650611.1	DUF4942 domain-containing protein	-
XM56_RS00400	104924..105292	-	369	WP_005165296.1	TA system toxin CbtA family protein	Toxin
XM56_RS20945	105356..105508	-	153	WP_129019424.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
XM56_RS00405	105577..106779	+	1203	WP_005176946.1	IS256 family transposase	-
XM56_RS00410	106954..108417	+	1464	WP_005166182.1	alpha/beta hydrolase	-
XM56_RS00415	108650..110056	-	1407	WP_013650609.1	filamentous hemagglutinin N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	102779..106779	4000

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (1-45)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13609.55 Da
• Isoelectric Point: 6.4731

>T53757 WP_005165296.1 NZ_CP011286:c105292-104924 [Yersinia enterocolitica]
MQTLPVTSKRAAYACLSPVIVWQSMLTYLLEQHYGLVLSDTEFSDDAVIHEHIDAGISLADALNFTVEKFDLARTDHRGF
SCQEQSPFITSIDILRARRATGLMTRMGYQTITSVIRGGKQA

Nucleotide

• Length: 369 bp

>T53757 NZ_CP011286:c105292-104924 [Yersinia enterocolitica]
ATGCAGACCTTACCTGTCACCTCGAAACGGGCGGCCTACGCTTGCCTATCACCCGTTATTGTCTGGCAATCCATGCTCAC
GTATCTGCTAGAGCAGCATTACGGCCTGGTGCTTAGCGACACCGAGTTCAGTGATGACGCCGTTATCCACGAACATATTG
ATGCCGGTATCTCTCTGGCTGATGCGCTGAATTTCACGGTGGAGAAGTTTGACTTGGCTCGCACCGATCACCGAGGTTTC
TCCTGCCAGGAACAATCTCCCTTTATCACGTCTATCGATATTCTCCGCGCTCGTCGAGCCACCGGTCTGATGACCCGTAT
GGGTTACCAGACCATCACCTCAGTTATCCGGGGAGGAAAGCAGGCATGA

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5593.44 Da
• Isoelectric Point: 4.5803

>AT53757 WP_129019424.1 NZ_CP011286:c105508-105356 [Yersinia enterocolitica]
MELMLLSGELNPRYQHCVTLYRNGLICEADSLGSQGYVYLAIYPTPQSIA

Nucleotide

• Length: 153 bp

>AT53757 NZ_CP011286:c105508-105356 [Yersinia enterocolitica]
CTGGAACTGATGCTGCTTTCTGGTGAGCTCAATCCCCGTTATCAGCACTGCGTCACGTTGTATCGCAATGGCTTGATCTG
CGAAGCCGATAGCCTGGGATCACAGGGTTATGTGTATCTCGCCATTTATCCTACTCCCCAATCAATTGCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7ISC5