Detailed information of TA system TA053708

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 13705..14242
• Replicon: plasmid pXfb33
• Accession: NZ_CP011251
• Organism: Xanthomonas citri pv. aurantifolii strain FDC 1561

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7X9YU06
• Locus tag: TP45_RS22830
• Protein ID: WP_017158383.1
• Coordinates: 13961..14242 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7X9UWY6
• Locus tag: TP45_RS22825
• Protein ID: WP_017158384.1
• Coordinates: 13705..13974 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TP45_RS22785	9102..9485	-	384	WP_123768333.1	hypothetical protein	-
TP45_RS22790	9583..9903	-	321	WP_007974210.1	type II toxin-antitoxin system PemK/MazF family toxin	-
TP45_RS22795	9903..10118	-	216	WP_011345582.1	antitoxin MazE family protein	-
TP45_RS22800	10366..10692	-	327	WP_007974207.1	hypothetical protein	-
TP45_RS22805	10689..11315	-	627	WP_007974205.1	ParA family protein	-
TP45_RS22810	11425..11673	-	249	WP_042806123.1	hypothetical protein	-
TP45_RS22815	11788..12474	+	687	WP_119866679.1	DNA-binding protein	-
TP45_RS22820	12634..13596	+	963	WP_007968792.1	recombinase family protein	-
TP45_RS22825	13705..13974	+	270	WP_017158384.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
TP45_RS22830	13961..14242	+	282	WP_017158383.1	type II toxin-antitoxin system YafQ family toxin	Toxin
TP45_RS22835	14563..14964	-	402	WP_007968789.1	hypothetical protein	-
TP45_RS22840	15123..15476	-	354	WP_042676252.1	hypothetical protein	-
TP45_RS22845	15522..16229	-	708	WP_007968786.1	hypothetical protein	-
TP45_RS22850	16226..16681	-	456	WP_007968784.1	hypothetical protein	-
TP45_RS22855	17070..17516	+	447	WP_007968782.1	hypothetical protein	-
TP45_RS22865	18037..18681	+	645	WP_007968779.1	hypothetical protein	-
TP45_RS22870	18727..19053	-	327	WP_007968778.1	type II toxin-antitoxin system PemK/MazF family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..33022	33022

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-93)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-86)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10679.06 Da
• Isoelectric Point: 8.9188

>T53708 WP_017158383.1 NZ_CP011251:13961-14242 [Xanthomonas citri pv. aurantifolii]
MRTIDRSSAFKRDYKREAKGQHRATLDDAIKPVLVALATDQPPDARYRDHDLSGDWAGYRECHIKPDLLLIYRKSDPDTL
RLARLGSHSELFG

Nucleotide

• Length: 282 bp

>T53708 NZ_CP011251:13961-14242 [Xanthomonas citri pv. aurantifolii]
ATGCGGACGATTGACCGTTCATCCGCTTTCAAGCGCGACTACAAGCGGGAAGCCAAGGGGCAGCATCGCGCCACGCTTGA
TGACGCGATCAAGCCGGTGTTGGTCGCACTGGCGACCGATCAGCCTCCCGATGCACGCTATCGCGATCACGATCTTTCCG
GCGATTGGGCGGGCTATCGGGAATGTCACATCAAGCCCGACTTGCTGCTGATCTACCGCAAGTCCGACCCCGACACCCTG
CGACTGGCACGGCTTGGCTCGCACAGCGAGCTTTTCGGCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9719.10 Da
• Isoelectric Point: 5.6976

>AT53708 WP_017158384.1 NZ_CP011251:13705-13974 [Xanthomonas citri pv. aurantifolii]
MSTTADTYVRARIDTATKERAASALEAMGLSISDAIRLLMLRIADEHRLPFDVKVPNTTTKKAIAELESGKGKKFANVDD
LMADLHADD

Nucleotide

• Length: 270 bp

>AT53708 NZ_CP011251:13705-13974 [Xanthomonas citri pv. aurantifolii]
ATGAGCACTACCGCCGATACCTACGTCCGCGCCCGCATCGACACCGCCACCAAGGAACGTGCCGCTAGTGCGCTCGAAGC
AATGGGGCTGTCGATCTCTGATGCTATCCGCCTGCTGATGCTACGCATTGCCGACGAACACCGCCTGCCCTTCGATGTGA
AGGTACCAAACACCACCACGAAAAAGGCGATTGCCGAACTGGAATCAGGCAAGGGTAAGAAGTTCGCCAATGTGGACGAC
CTGATGGCGGATTTGCATGCGGACGATTGA

Structures

Toxin

• AlphaFold DB: A0A7X9YU06

Antitoxin

• AlphaFold DB: A0A7X9UWY6