Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdB-vagC/VagC(antitoxin)
Location 4393790..4394413 Replicon chromosome
Accession NZ_CP011104
Organism Photorhabdus thracensis strain DSM 15199

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0F7LPL1
Locus tag VY86_RS19185 Protein ID WP_046976150.1
Coordinates 4394099..4394413 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A0F7LTE2
Locus tag VY86_RS19180 Protein ID WP_046976149.1
Coordinates 4393790..4394011 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VY86_RS23705 4388891..4389205 + 315 WP_082111263.1 phosphatase PAP2 family protein -
VY86_RS19150 4389375..4389686 + 312 WP_046976144.1 LapA family protein -
VY86_RS19155 4389693..4390862 + 1170 WP_046976145.1 lipopolysaccharide assembly protein LapB -
VY86_RS19160 4390907..4391653 + 747 WP_046976146.1 orotidine-5'-phosphate decarboxylase -
VY86_RS19165 4391643..4391969 + 327 WP_021325445.1 stress response translation initiation inhibitor YciH -
VY86_RS19170 4392577..4393182 + 606 WP_046976147.1 TetR/AcrR family transcriptional regulator -
VY86_RS19175 4393219..4393698 + 480 WP_046976148.1 nuclear transport factor 2 family protein -
VY86_RS19180 4393790..4394011 - 222 WP_046976149.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
VY86_RS19185 4394099..4394413 - 315 WP_046976150.1 CcdB family protein Toxin
VY86_RS19190 4394416..4394652 - 237 WP_046976151.1 type II toxin-antitoxin system CcdA family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11786.73 Da        Isoelectric Point: 5.7946

>T53367 WP_046976150.1 NZ_CP011104:c4394413-4394099 [Photorhabdus thracensis]
MQFTVYRNTGKTVVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPDSSRPVRMIPLIRLIDDKEYAVMTQELASISVHALG
AEFCDASQYRNQVKAALDFLFDGI

Download         Length: 315 bp

>T53367 NZ_CP011104:c4394413-4394099 [Photorhabdus thracensis]
ATGCAATTCACCGTTTACCGTAATACTGGGAAAACCGTTGTTTATCCCCTGTTGCTGGACGTCACGAGTGACATTATCGG
GCAGTTAAACCGCCGAATTGTGATCCCACTGCTGCCAGTTGAAAAATATCCTGACAGCAGTCGCCCTGTTCGAATGATCC
CCCTTATCAGGCTGATAGATGACAAAGAATATGCTGTCATGACTCAAGAACTAGCCAGTATATCTGTTCATGCTTTGGGT
GCTGAATTTTGCGATGCATCGCAATACCGTAATCAGGTAAAGGCGGCACTCGATTTCCTCTTTGACGGTATTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8381.67 Da        Isoelectric Point: 4.5408

>AT53367 WP_046976149.1 NZ_CP011104:c4394011-4393790 [Photorhabdus thracensis]
MCTVAIFKNSNNRAIRLPKDMDFDGIAELEIFRIEDSIILKPIKPTWDSFLSQEKADNNFLGPDIIEEGRVKL

Download         Length: 222 bp

>AT53367 NZ_CP011104:c4394011-4393790 [Photorhabdus thracensis]
ATGTGTACCGTAGCGATATTTAAAAACAGTAATAACCGGGCAATAAGACTCCCAAAAGATATGGATTTTGATGGTATCGC
CGAATTAGAAATTTTCCGTATCGAGGACTCCATTATTCTGAAACCAATAAAACCTACATGGGATTCTTTTCTGTCACAGG
AAAAAGCTGATAATAATTTTTTAGGCCCTGATATTATCGAAGAAGGTCGCGTGAAATTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F7LPL1

Antitoxin

Source ID Structure
AlphaFold DB A0A0F7LTE2

References