Detailed information of TA system TA052865

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 607077..607657
• Replicon: chromosome
• Accession: NZ_CP010802
• Organism: Desulfuromonas soudanensis strain WTL

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: DSOUD_RS17670
• Protein ID: WP_082351026.1
• Coordinates: 607077..607331 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0M4D798
• Locus tag: DSOUD_RS02595
• Protein ID: WP_053549539.1
• Coordinates: 607328..607657 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DSOUD_RS02570	602693..602971	+	279	WP_053549534.1	DUF1778 domain-containing protein	-
DSOUD_RS02575	602958..603464	+	507	WP_053549535.1	GNAT family N-acetyltransferase	-
DSOUD_RS02580	603774..604154	+	381	WP_053549536.1	DUF2007 domain-containing protein	-
DSOUD_RS18660	604389..606206	+	1818	WP_198300353.1	diguanylate cyclase	-
DSOUD_RS02590	606269..606673	+	405	WP_053549538.1	PaaI family thioesterase	-
DSOUD_RS17670	607077..607331	+	255	WP_082351026.1	type II toxin-antitoxin system HicA family toxin	Toxin
DSOUD_RS02595	607328..607657	+	330	WP_053549539.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DSOUD_RS02600	608635..609048	+	414	WP_053549540.1	(deoxy)nucleoside triphosphate pyrophosphohydrolase	-
DSOUD_RS18255	609230..609730	+	501	WP_157671703.1	hypothetical protein	-
DSOUD_RS02605	610414..612522	+	2109	WP_053549541.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (60-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9491.96 Da
• Isoelectric Point: 10.9867

>T52865 WP_082351026.1 NZ_CP010802:607077-607331 [Desulfuromonas soudanensis]
MNSQHRKTLLALFAQPVPANLEWRRIEALFLALGAEMVEGAGSRVAFVLHDRRADFHRPHPGKEAKRYQVRAAREFLEAA
GVTL

Nucleotide

• Length: 255 bp

>T52865 NZ_CP010802:607077-607331 [Desulfuromonas soudanensis]
ATGAACAGTCAGCATCGCAAAACGCTACTGGCGTTATTCGCCCAGCCCGTCCCGGCCAATCTGGAATGGCGGCGCATCGA
GGCCCTGTTTCTTGCCCTTGGCGCAGAAATGGTCGAAGGGGCCGGGTCACGAGTGGCTTTCGTGCTCCATGACCGGCGGG
CCGACTTTCATCGTCCGCATCCCGGCAAGGAAGCAAAACGTTACCAAGTGCGGGCGGCGCGGGAATTTCTCGAAGCTGCA
GGAGTCACCTTATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11964.79 Da
• Isoelectric Point: 6.3245

>AT52865 WP_053549539.1 NZ_CP010802:607328-607657 [Desulfuromonas soudanensis]
MSKPLTYNGYAAHVEFDAEDRLFVGRIAGIIDIVTFHGESVTELEQAFQAAVDDYLLMSEKLGRKPQKPCSGKLMLRIPP
EVHAHAVMMAAAHGKSLNQWAADVLAKAE

Nucleotide

• Length: 330 bp

>AT52865 NZ_CP010802:607328-607657 [Desulfuromonas soudanensis]
ATGAGCAAACCCCTTACCTATAACGGCTACGCGGCGCACGTCGAGTTTGACGCCGAAGATCGGTTGTTTGTCGGCCGCAT
CGCCGGGATCATCGACATCGTCACCTTTCACGGTGAATCGGTGACGGAGCTGGAGCAGGCATTTCAGGCTGCCGTCGACG
ATTACCTCCTTATGTCCGAGAAACTCGGACGCAAACCGCAAAAACCCTGCTCCGGCAAGCTTATGCTGCGCATCCCCCCG
GAAGTCCATGCGCACGCGGTGATGATGGCCGCGGCGCACGGCAAGAGTCTGAACCAGTGGGCAGCGGATGTGCTGGCCAA
AGCGGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0M4D798