Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5214364..5216215 Replicon chromosome
Accession NZ_CP010518
Organism Pandoraea apista strain TF81F4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag SG18_RS23525 Protein ID WP_052765530.1
Coordinates 5214364..5215272 (+) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag SG18_RS23530 Protein ID WP_082117814.1
Coordinates 5215274..5216215 (+) Length 314 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG18_RS23500 5209783..5210859 + 1077 WP_042118075.1 porin -
SG18_RS23505 5211261..5212034 + 774 WP_082118012.1 ABC transporter ATP-binding protein -
SG18_RS23510 5212073..5212855 + 783 WP_042114934.1 ABC transporter permease -
SG18_RS23515 5212871..5213665 + 795 WP_042114936.1 SDR family oxidoreductase -
SG18_RS23520 5213707..5214264 + 558 WP_042114937.1 cupin domain-containing protein -
SG18_RS23525 5214364..5215272 + 909 WP_052765530.1 alpha/beta fold hydrolase Toxin
SG18_RS23530 5215274..5216215 + 942 WP_082117814.1 IclR family transcriptional regulator Antitoxin
SG18_RS23535 5216212..5217018 + 807 WP_042114938.1 SDR family oxidoreductase -
SG18_RS23540 5217011..5218663 + 1653 WP_042114940.1 thiamine pyrophosphate-binding protein -
SG18_RS23545 5218656..5219474 + 819 WP_042114941.1 aspartate dehydrogenase -
SG18_RS23550 5219488..5220984 + 1497 WP_042114942.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, C-terminal

(168-291)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31363.44 Da        Isoelectric Point: 5.8839

>T52744 WP_052765530.1 NZ_CP010518:5214364-5215272 [Pandoraea apista]
MQAEASLSEVPEDAAVAPLRARLNAFPYRTLATRTGTVGYRCAGAHAEGGMPVVMLHGIGSGAASWLAQFEATGLNAELY
AWDAPGYGQTSNVADAEPHADAYADALEAWLDALGLKRVALVGHSLGAIMATKFASRSPQRVSGLFLCSPAGGYGKADPD
VRVSKRDSRLAMLDKLGPAGMARERSDNLVAPNAADLPRSWVKWNMARVHPAGYRQATHLLSNGDVAGELAQYVAANAGP
VAVAVGAQDAITTPAACQTIADVAGVPLQIIEGAGHASYIETPDVLNAALAAWLERIAAGER

Download         Length: 909 bp

>T52744 NZ_CP010518:5214364-5215272 [Pandoraea apista]
ATGCAAGCCGAAGCCTCACTGTCCGAAGTGCCCGAAGATGCCGCCGTCGCACCGCTGCGCGCGCGTCTGAATGCTTTCCC
GTACCGCACGCTCGCCACGCGTACGGGCACCGTCGGCTATCGCTGCGCTGGCGCGCATGCCGAGGGTGGCATGCCGGTCG
TGATGCTGCACGGCATTGGGTCCGGCGCGGCGTCATGGCTGGCGCAGTTCGAAGCCACAGGGCTTAACGCCGAGCTTTAC
GCGTGGGACGCCCCGGGCTATGGGCAGACGTCGAACGTCGCCGATGCCGAGCCGCATGCCGATGCTTACGCCGACGCGCT
TGAGGCGTGGCTCGATGCCCTGGGGCTCAAGCGTGTCGCTCTCGTTGGCCACTCGCTGGGCGCGATCATGGCGACGAAGT
TTGCGAGCCGCTCCCCGCAGCGTGTGAGTGGACTCTTTCTCTGCTCGCCGGCCGGCGGTTACGGCAAGGCCGATCCGGAC
GTGCGCGTAAGCAAGCGCGATAGCCGTCTGGCGATGCTCGACAAGCTGGGCCCGGCCGGCATGGCCCGCGAGCGCAGCGA
CAATCTCGTCGCGCCGAATGCCGCAGACCTGCCGCGCTCCTGGGTGAAATGGAACATGGCGCGCGTGCATCCCGCCGGAT
ACCGGCAGGCGACGCACCTTCTCTCGAACGGCGACGTCGCCGGCGAGTTGGCGCAATACGTGGCCGCGAACGCCGGGCCG
GTGGCCGTGGCGGTCGGCGCACAGGATGCGATCACGACGCCCGCAGCTTGCCAGACGATTGCCGACGTGGCCGGCGTGCC
ACTGCAGATCATCGAAGGCGCGGGACACGCGTCGTACATCGAAACCCCGGACGTTCTGAACGCCGCGCTCGCGGCGTGGC
TCGAGCGCATCGCGGCAGGAGAGCGCTGA

Antitoxin


Download         Length: 314 a.a.        Molecular weight: 34121.88 Da        Isoelectric Point: 6.3621

>AT52744 WP_082117814.1 NZ_CP010518:5215274-5216215 [Pandoraea apista]
MAPATPKRAAAAPDAQIEDDKLGLQDTQTDGDELAEGSTSDTRYLVPGLERGLRILTQFSPREAVFSAPELSQRLGIPRT
TVFRLLQTLEAMGFLERAGSEKNFRLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQS
VAGVFNSIKVNVGTRLPAHATVHGHVLMGDLTLAELRALYPEKTLEKYTPQTPETLAELFERVREDAERGYAVSASSFER
GISVVSAPVRNDAGRICAAITVTIPRANIDSSMLDAGLIGQVREAADALSHRLNYRPGSDRQPTPYMKSLGLK

Download         Length: 942 bp

>AT52744 NZ_CP010518:5215274-5216215 [Pandoraea apista]
ATGGCACCGGCAACCCCGAAGCGCGCAGCGGCAGCGCCCGACGCGCAGATCGAAGACGACAAGCTCGGTCTTCAGGACAC
CCAGACCGATGGCGACGAACTCGCCGAAGGTTCAACGTCCGACACCCGTTATCTCGTGCCCGGTCTGGAGCGCGGCTTGC
GCATTCTTACGCAGTTCTCGCCGCGCGAGGCCGTATTCAGCGCGCCGGAGTTGTCGCAACGCCTCGGCATTCCGCGTACC
ACCGTTTTCCGTTTGTTGCAGACGCTTGAAGCGATGGGTTTTCTGGAGCGCGCGGGGAGCGAGAAGAATTTCCGTCTGGG
CGTGGCAGTGCTGCGTCTGGGCTTCGAATACCTCAGTTCGCTGGAGTTGACCGATCTGGGGATTCCGATCATCGAACGGC
TGCGCGACGCCACGCAATTGACCTCGCACATCGTGATCCGGGACGGGCGAGACATCGTGTTCGTGGCGAAGGCGCAAAGC
GTTGCCGGCGTTTTCAATTCGATCAAGGTAAACGTCGGCACGCGTCTGCCGGCGCATGCAACGGTGCATGGCCATGTGCT
GATGGGCGACCTGACGCTGGCCGAGCTTCGTGCGCTGTATCCGGAAAAGACGCTAGAAAAATACACGCCGCAAACGCCCG
AGACGCTTGCGGAGTTGTTCGAACGGGTGCGTGAAGACGCCGAGCGCGGTTACGCGGTGTCGGCTTCGTCGTTCGAGCGG
GGCATCAGTGTCGTGAGTGCACCGGTGCGCAACGACGCGGGCCGTATCTGCGCCGCCATCACCGTGACCATTCCGCGCGC
CAACATCGATTCGTCAATGCTCGATGCGGGGCTGATCGGACAGGTGCGCGAGGCGGCCGATGCGCTGTCGCATCGTCTGA
ACTATCGACCGGGCAGCGACCGTCAACCCACCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References