Detailed information of TA system TA052365

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 169930..170419
• Replicon: chromosome
• Accession: NZ_CP010411
• Organism: Bifidobacterium longum subsp. infantis strain BT1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: RY67_RS00675
• Protein ID: WP_060620047.1
• Coordinates: 169930..170199 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4R0VXI9
• Locus tag: RY67_RS00680
• Protein ID: WP_060620048.1
• Coordinates: 170183..170419 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RY67_RS00660	167266..167988	-	723	WP_060620046.1	hypothetical protein	-
RY67_RS00665	168052..169008	-	957	WP_060621457.1	A/G-specific adenine glycosylase	-
RY67_RS00670	169029..169691	+	663	WP_003828427.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
RY67_RS00675	169930..170199	-	270	WP_060620047.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
RY67_RS00680	170183..170419	-	237	WP_060620048.1	ribbon-helix-helix domain-containing protein	Antitoxin
RY67_RS11140	171002..171715	-	714	WP_082247953.1	4'-phosphopantetheinyl transferase superfamily protein	-
RY67_RS00685	171726..172943	-	1218	WP_082248145.1	MFS transporter	-
RY67_RS00690	173078..174265	-	1188	WP_060620049.1	carboxylate--amine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10340.17 Da
• Isoelectric Point: 10.3382

>T52365 WP_060620047.1 NZ_CP010411:c170199-169930 [Bifidobacterium longum subsp. infantis]
MSWRIEIDKGVQRSMKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVA
HRSKVYKRC

Nucleotide

• Length: 270 bp

>T52365 NZ_CP010411:c170199-169930 [Bifidobacterium longum subsp. infantis]
TTGTCTTGGAGGATTGAGATTGACAAGGGCGTCCAGCGTTCGATGAAGAAGCTGGATCGTAATGTTGCCAAGAGAATCAT
CGCAAAGCTTAGGGAAATTTCACAGTTGGAAGATCCGAGAAGCACCGGCAAGGCTCTTGCCGGTAATCTGGCAGGGCTGT
GGCGTTACCGTGTCGGGGACTATCGTATCGTGTGCGATATAGAGGATGAGGTTCTGCTGATTCTTGTGATTGATGTCGCG
CACAGGAGCAAGGTGTACAAGCGTTGCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8970.23 Da
• Isoelectric Point: 4.2821

>AT52365 WP_060620048.1 NZ_CP010411:c170419-170183 [Bifidobacterium longum subsp. infantis]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLVLED

Nucleotide

• Length: 237 bp

>AT52365 NZ_CP010411:c170419-170183 [Bifidobacterium longum subsp. infantis]
ATGGCCACGGTTACTGCAGCATTAAGGATGCCTGTCGAATTGGCGGCTCGTTACGATTGTCTGGCGAAAGCGACTGGTCG
TACGAAGACGTTTTACATGAACGAAGCCCTTACCGAATCGATCGATAGGTTTGAGTATGAATACGGCATTATGAAAAAGG
TCGAGGATTGGCGTGCCGGCAGACTCGAAACCGTGACGCTCGACGAGCTGGAGGAAAGCCTTGTCTTGGAGGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A4R0VXI9