Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 3228222..3228702 Replicon chromosome
Accession NZ_CP010311
Organism Geoalkalibacter subterraneus strain Red1

Toxin (Protein)


Gene name relE Uniprot ID A0A0B5FSI7
Locus tag GSUB_RS15125 Protein ID WP_040201550.1
Coordinates 3228430..3228702 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0B5FJS6
Locus tag GSUB_RS15120 Protein ID WP_040201549.1
Coordinates 3228222..3228446 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GSUB_RS15100 3224097..3225662 - 1566 WP_084212145.1 sigma-54 dependent transcriptional regulator -
GSUB_RS15105 3225941..3226738 - 798 WP_040201548.1 ABC transporter permease -
GSUB_RS15110 3226735..3227397 - 663 WP_052464986.1 ATP-binding cassette domain-containing protein -
GSUB_RS19675 3227572..3228000 + 429 WP_052464987.1 hypothetical protein -
GSUB_RS15120 3228222..3228446 + 225 WP_040201549.1 TraY domain-containing protein Antitoxin
GSUB_RS15125 3228430..3228702 + 273 WP_040201550.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GSUB_RS15130 3228743..3229936 + 1194 WP_040201551.1 Xaa-Pro peptidase family protein -
GSUB_RS15135 3230015..3230419 - 405 WP_040201552.1 hypothetical protein -
GSUB_RS15140 3230686..3231624 - 939 WP_040201554.1 transposase -
GSUB_RS15145 3231699..3232883 - 1185 WP_144402044.1 WD40 repeat domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10843.72 Da        Isoelectric Point: 10.7207

>T51985 WP_040201550.1 NZ_CP010311:3228430-3228702 [Geoalkalibacter subterraneus]
MAWRIEITRTARKQLTKLDRQIQVDILRYLREKIATDDDPRRYGGPLRRDLAGRWKYRVGSYRLICEIQDEKILVLVLMV
GHRGKIYERT

Download         Length: 273 bp

>T51985 NZ_CP010311:3228430-3228702 [Geoalkalibacter subterraneus]
TTGGCCTGGCGGATTGAAATTACGCGCACCGCCCGCAAACAGCTGACCAAACTCGATCGCCAGATCCAGGTCGATATTCT
ACGCTATCTGCGGGAGAAGATCGCAACCGATGATGATCCGCGCCGCTATGGCGGGCCTTTGAGAAGAGACCTCGCCGGGC
GGTGGAAATACCGCGTCGGGAGCTATCGGCTGATCTGCGAAATTCAGGATGAAAAAATTCTGGTCCTTGTACTGATGGTC
GGACACCGTGGGAAAATTTATGAAAGAACCTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8518.56 Da        Isoelectric Point: 4.3135

>AT51985 WP_040201549.1 NZ_CP010311:3228222-3228446 [Geoalkalibacter subterraneus]
MLALRLPEDIERRLEALAKRSGRSKSFYAREAILEHLDDLEAAYLSDEILQRVENGTEPTYTLDELERQLGLAD

Download         Length: 225 bp

>AT51985 NZ_CP010311:3228222-3228446 [Geoalkalibacter subterraneus]
ATGCTTGCACTACGCCTTCCTGAAGACATTGAACGCCGCCTGGAGGCGCTGGCAAAACGCTCAGGCCGCTCCAAATCCTT
TTACGCCCGCGAGGCCATCCTCGAACATCTCGATGACCTCGAGGCCGCCTATCTTTCCGACGAAATTCTCCAGCGCGTCG
AAAACGGCACGGAACCAACCTACACCCTCGACGAACTGGAGCGTCAACTTGGCCTGGCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B5FSI7

Antitoxin

Source ID Structure
AlphaFold DB A0A0B5FJS6

References