Detailed information of TA system TA051979

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1582140..1582684
• Replicon: chromosome
• Accession: NZ_CP010311
• Organism: Geoalkalibacter subterraneus strain Red1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GSUB_RS07265
• Protein ID: WP_144401976.1
• Coordinates: 1582409..1582684 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0B5FQL1
• Locus tag: GSUB_RS07260
• Protein ID: WP_040199985.1
• Coordinates: 1582140..1582409 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GSUB_RS19025	1577166..1578473	+	1308	WP_052464707.1	TIGR04283 family arsenosugar biosynthesis glycosyltransferase	-
GSUB_RS07245	1578670..1579497	-	828	WP_040199982.1	nitroreductase family protein	-
GSUB_RS07250	1579548..1580864	+	1317	WP_040199983.1	alpha/beta fold hydrolase	-
GSUB_RS07255	1580854..1581606	+	753	WP_040199984.1	VacJ family lipoprotein	-
GSUB_RS07260	1582140..1582409	+	270	WP_040199985.1	ribbon-helix-helix domain-containing protein	Antitoxin
GSUB_RS07265	1582409..1582684	+	276	WP_144401976.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GSUB_RS07270	1583356..1584390	+	1035	WP_040199987.1	hypothetical protein	-
GSUB_RS07275	1584644..1585849	+	1206	WP_040199988.1	hypothetical protein	-
GSUB_RS07280	1586087..1587298	+	1212	WP_144401977.1	cytochrome C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10810.43 Da
• Isoelectric Point: 8.5040

>T51979 WP_144401976.1 NZ_CP010311:1582409-1582684 [Geoalkalibacter subterraneus]
MVLKWTGRAVSDLERLYEFLALVNREAAARTVQALTRAPTSLLANPRIGEKLEEFEPREVRRILVGHYELRYEIQESTIY
VLRLWHTREDR

Nucleotide

• Length: 276 bp

>T51979 NZ_CP010311:1582409-1582684 [Geoalkalibacter subterraneus]
ATGGTGCTGAAGTGGACAGGAAGAGCAGTTTCTGACCTGGAGCGGCTTTATGAATTTTTGGCGTTGGTGAACCGGGAAGC
GGCTGCGCGCACGGTGCAGGCCCTCACCAGGGCCCCGACCAGCTTGTTGGCAAACCCACGCATCGGCGAAAAGCTCGAAG
AATTCGAGCCACGCGAAGTTCGCCGAATTCTCGTCGGGCACTATGAGCTGCGCTACGAAATTCAGGAATCCACGATCTAC
GTGCTACGGTTGTGGCATACCCGCGAGGATCGATAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10040.43 Da
• Isoelectric Point: 5.1239

>AT51979 WP_040199985.1 NZ_CP010311:1582140-1582409 [Geoalkalibacter subterraneus]
MPQVKTKVLTAHVPIPLAEKVDQMAERLDRSRGWIMKQALSAWVDQEEERSRLTREALADVDAGSVIDHQAVQAWAESLD
NDKPLPVPR

Nucleotide

• Length: 270 bp

>AT51979 NZ_CP010311:1582140-1582409 [Geoalkalibacter subterraneus]
ATGCCACAGGTAAAAACCAAAGTCCTTACAGCACATGTGCCTATCCCGTTGGCCGAAAAGGTCGATCAGATGGCCGAGCG
CCTCGACCGGTCCCGTGGTTGGATCATGAAGCAGGCCCTGTCGGCCTGGGTCGACCAGGAAGAAGAACGCAGTCGCCTTA
CCCGGGAGGCCCTGGCTGACGTGGATGCCGGCAGCGTTATCGACCATCAGGCCGTGCAGGCATGGGCCGAAAGTCTGGAT
AACGACAAACCGTTGCCCGTGCCGCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0B5FQL1