Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3233264..3233522 Replicon chromosome
Accession NZ_CP010200
Organism Escherichia coli strain M10

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag RG59_RS16855 Protein ID WP_000935262.1
Coordinates 3233264..3233473 (-) Length 70 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3233465..3233522 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG59_RS16835 3228505..3229218 - 714 WP_001102383.1 acidic protein MsyB -
RG59_RS16840 3229244..3229648 - 405 WP_000843559.1 DUF2541 family protein -
RG59_RS16845 3230025..3231941 + 1917 WP_000516135.1 molecular chaperone DnaK -
RG59_RS16850 3232030..3233160 + 1131 WP_001118464.1 molecular chaperone DnaJ -
RG59_RS16855 3233264..3233473 - 210 WP_000935262.1 type I toxin-antitoxin system Hok family toxin Toxin
- 3233465..3233522 + 58 - - Antitoxin
RG59_RS16860 3234002..3235168 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
RG59_RS16865 3235228..3236133 + 906 WP_000062888.1 transcriptional activator NhaR -
RG59_RS16870 3236172..3237131 - 960 WP_000871656.1 hypothetical protein -
RG59_RS16875 3237144..3238496 - 1353 Protein_3078 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(25-66)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7742.28 Da        Isoelectric Point: 9.3680

>T51342 WP_000935262.1 NZ_CP010200:c3233473-3233264 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 210 bp

>T51342 NZ_CP010200:c3233473-3233264 [Escherichia coli]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT51342 NZ_CP010200:3233465-3233522 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References