Detailed information of TA system TA050877

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4426474..4426696
• Replicon: chromosome
• Accession: NZ_CP010151
• Organism: Escherichia coli strain D8

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A0D6GD35
• Locus tag: RG41_RS23000
• Protein ID: WP_000170745.1
• Coordinates: 4426589..4426696 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4426474..4426532 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RG41_RS22970	4421915..4422817	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
RG41_RS22975	4422828..4423811	+	984	WP_001196477.1	dipeptide ABC transporter ATP-binding protein	-
RG41_RS22980	4423808..4424812	+	1005	WP_000103583.1	dipeptide ABC transporter ATP-binding subunit DppF	-
RG41_RS22985	4424842..4426113	-	1272	WP_001467807.1	amino acid permease	-
-	4426474..4426532	-	59	-	-	Antitoxin
RG41_RS23000	4426589..4426696	+	108	WP_000170745.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
RG41_RS23005	4426783..4428462	-	1680	WP_000191567.1	cellulose biosynthesis protein BcsG	-
RG41_RS23010	4428459..4428650	-	192	WP_000988311.1	cellulose biosynthesis protein BcsF	-
RG41_RS23015	4428647..4430218	-	1572	WP_001204945.1	cellulose biosynthesis protein BcsE	-
RG41_RS23020	4430491..4430679	+	189	WP_001063314.1	YhjR family protein	-
RG41_RS23025	4430691..4431442	+	752	Protein_4109	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3855.68 Da
• Isoelectric Point: 9.0157

>T50877 WP_000170745.1 NZ_CP010151:4426589-4426696 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVSWLNKRK

Nucleotide

• Length: 108 bp

>T50877 NZ_CP010151:4426589-4426696 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT50877 NZ_CP010151:c4426532-4426474 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A0D6GD35

Antitoxin