Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4437577..4437835 Replicon chromosome
Accession NZ_CP010121
Organism Escherichia coli strain C4

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag RG27_RS22785 Protein ID WP_000809168.1
Coordinates 4437683..4437835 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4437577..4437634 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RG27_RS22770 4433969..4434928 + 960 WP_000871674.1 hypothetical protein -
RG27_RS22775 4434966..4435865 - 900 WP_001300855.1 transcriptional activator NhaR -
RG27_RS22780 4435931..4437097 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 4437577..4437634 - 58 - - Antitoxin
RG27_RS22785 4437683..4437835 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
RG27_RS22790 4437939..4439069 - 1131 WP_001118464.1 molecular chaperone DnaJ -
RG27_RS22795 4439158..4441074 - 1917 WP_000516135.1 molecular chaperone DnaK -
RG27_RS22800 4441450..4441854 + 405 WP_000843584.1 DUF2541 family protein -
RG27_RS22805 4441880..4442593 + 714 WP_001102367.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T50475 WP_000809168.1 NZ_CP010121:4437683-4437835 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T50475 NZ_CP010121:4437683-4437835 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT50475 NZ_CP010121:c4437634-4437577 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References