50124

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1667811..1668288 Replicon chromosome
Accession NZ_CP009885
Organism Xylella fastidiosa strain Hib4

Toxin (Protein)


Gene name pasB Uniprot ID A0A1L2B0S8
Locus tag XFHB_RS08475 Protein ID WP_023907681.1
Coordinates 1668022..1668288 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A1L2AR28
Locus tag XFHB_RS08470 Protein ID WP_031336679.1
Coordinates 1667811..1668038 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XFHB_RS08435 1663027..1663587 - 561 WP_088578044.1 DUF2612 domain-containing protein -
XFHB_RS08440 1663584..1664729 - 1146 WP_088578043.1 baseplate J/gp47 family protein -
XFHB_RS08445 1664822..1665175 - 354 WP_088578155.1 hypothetical protein -
XFHB_RS08450 1665172..1665813 - 642 WP_088578156.1 hypothetical protein -
XFHB_RS08455 1665810..1666640 - 831 WP_023906521.1 hypothetical protein -
XFHB_RS08460 1666637..1666930 - 294 WP_088578040.1 hypothetical protein -
XFHB_RS08465 1666930..1667700 - 771 WP_088578039.1 hypothetical protein -
XFHB_RS08470 1667811..1668038 + 228 WP_031336679.1 CopG family transcriptional regulator Antitoxin
XFHB_RS08475 1668022..1668288 + 267 WP_023907681.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
XFHB_RS08480 1668300..1670189 - 1890 WP_088578157.1 hypothetical protein -
XFHB_RS08485 1670337..1670759 - 423 WP_088578158.1 hypothetical protein -
XFHB_RS08490 1670756..1671193 - 438 WP_088578159.1 DUF3277 family protein -
XFHB_RS08495 1671203..1672699 - 1497 WP_088578160.1 DUF3383 domain-containing protein -
XFHB_RS08500 1672700..1673233 - 534 WP_194955731.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1657505..1686114 28609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10176.88 Da        Isoelectric Point: 10.9777

>T50124 WP_023907681.1 NZ_CP009885:1668022-1668288 [Xylella fastidiosa]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSTGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGKIYR

Download         Length: 267 bp

>T50124 NZ_CP009885:1668022-1668288 [Xylella fastidiosa]
TTGGCCTGGACGATTGATTACACCGACACGGCCAAGCAGCAGTTACGCAAACTCGACAAGCACATGGCGCGGCGCATTGT
CGATTTCATGGATGAGCGCATCGCCGGACTAGAAAACCCACGCAGCACTGGTAAAGCATTAACCGGACCACTTGGCGGCT
TTTGGCGTTATCGTGTTGGTGATTTCCGGGTCGTCTGCGCCATTCAAGATAGCGTTTTGCGCGTCCTTGTAGTGCGTGTT
GGTCACCGGGGTAAGATTTACCGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8691.73 Da        Isoelectric Point: 5.0958

>AT50124 WP_031336679.1 NZ_CP009885:1667811-1668038 [Xylella fastidiosa]
MATSIRLSPEMEQRLNYLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Download         Length: 228 bp

>AT50124 NZ_CP009885:1667811-1668038 [Xylella fastidiosa]
ATGGCGACTTCGATTCGCCTCTCTCCTGAAATGGAGCAAAGGCTGAACTATCTTGCCTCCCATACGGGACGCACAAAGGC
TTACTACCTGCGTGAAATCATTGAGCATGGCATTGAGGAAATGGAGGATTACTACCTTGCTGCCGATGTATTGGAGCGTG
TCCGTCATGGACAAGAACAGGTGCATTCTGCTGCCGACGTGAGGAAAACGCTTGGCCTGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L2B0S8

Antitoxin

Source ID Structure
AlphaFold DB A0A1L2AR28

References