Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3811342..3812057 Replicon chromosome
Accession NZ_CP009850
Organism UNVERIFIED_ORG: Enterobacter cloacae strain ECNIH4

Toxin (Protein)


Gene name ypjF Uniprot ID A0A8I0UM05
Locus tag ECNIH4_RS24395 Protein ID WP_023303149.1
Coordinates 3811342..3811710 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A8I0UJV2
Locus tag ECNIH4_RS18200 Protein ID WP_023303148.1
Coordinates 3811731..3812057 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECNIH4_RS18165 (ECNIH4_18165) 3806365..3806793 + 429 WP_032638336.1 hypothetical protein -
ECNIH4_RS18170 (ECNIH4_18170) 3806769..3807332 + 564 Protein_3575 IS3 family transposase -
ECNIH4_RS18175 (ECNIH4_18175) 3807487..3808350 + 864 WP_001065553.1 GTPase family protein -
ECNIH4_RS18180 (ECNIH4_18180) 3808442..3809263 + 822 WP_000197389.1 DUF932 domain-containing protein -
ECNIH4_RS18185 (ECNIH4_18185) 3809480..3810181 + 702 WP_006812588.1 WYL domain-containing protein -
ECNIH4_RS18190 (ECNIH4_18190) 3810222..3810458 + 237 WP_001144031.1 protein YpjK -
ECNIH4_RS18195 (ECNIH4_18195) 3810458..3810901 + 444 WP_000824223.1 lipoprotein YafY -
ECNIH4_RS25355 3810925..3811020 + 96 Protein_3581 hypothetical protein -
ECNIH4_RS24395 3811342..3811710 - 369 WP_023303149.1 TA system toxin CbtA family protein Toxin
ECNIH4_RS18200 (ECNIH4_18200) 3811731..3812057 - 327 WP_023303148.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECNIH4_RS18205 (ECNIH4_18205) 3812070..3812540 - 471 WP_023303147.1 DNA repair protein RadC -
ECNIH4_RS18210 (ECNIH4_18210) 3812606..3813427 - 822 WP_023303146.1 DUF932 domain-containing protein -
ECNIH4_RS18220 (ECNIH4_18220) 3814117..3814956 - 840 WP_023303145.1 hypothetical protein -
ECNIH4_RS18225 (ECNIH4_18225) 3815015..3815449 - 435 WP_023303144.1 hypothetical protein -
ECNIH4_RS18230 (ECNIH4_18230) 3815758..3817023 - 1266 WP_038421272.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3806790..3807332 542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13727.91 Da        Isoelectric Point: 8.2822

>T49988 WP_023303149.1 NZ_CP009850:c3811710-3811342 [Enterobacter cloacae]
MKNLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIILADAVNFLVDKYELVRIDRRGF
SSQGQVPYLTVTDILHARRACGLMKSCSYREVSNIVLSHSRQ

Download         Length: 369 bp

>T49988 NZ_CP009850:c3811710-3811342 [Enterobacter cloacae]
ATGAAAAATCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTCTGCTTGAACAGCACTATGGTCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTAATTAAGGAACATATTG
ATGCTGGGATTATCCTGGCCGATGCAGTCAACTTCCTGGTAGATAAGTACGAACTGGTTCGCATTGATCGCAGAGGATTT
AGCTCACAGGGACAAGTACCATATTTGACCGTGACAGATATCCTTCATGCCAGAAGAGCATGTGGATTAATGAAAAGTTG
CTCTTATCGGGAAGTAAGTAATATTGTTCTTAGTCATTCGCGGCAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12215.04 Da        Isoelectric Point: 7.0266

>AT49988 WP_023303148.1 NZ_CP009850:c3812057-3811731 [Enterobacter cloacae]
MSLIPAHEWGIKSDIVPRLGVRLVQEGNRLHYLADRASITGKFSDAECLKLDIVFPHFIRQMESMLTTGEMNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 327 bp

>AT49988 NZ_CP009850:c3812057-3811731 [Enterobacter cloacae]
ATGTCATTAATACCAGCCCATGAATGGGGGATAAAAAGCGATATTGTTCCACGGCTTGGAGTCAGATTAGTTCAGGAAGG
CAACCGGCTGCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTCAGTGACGCCGAATGCCTGAAGTTGGATATCG
TATTTCCGCATTTTATCCGTCAGATGGAATCGATGCTGACCACTGGTGAAATGAATTCTCGCCATGCCCACTGTGTCACT
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATACATCGCCATTTATCCCACTCA
ACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References