Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 3169714..3170627 Replicon chromosome
Accession NZ_CP009850
Organism UNVERIFIED_ORG: Enterobacter cloacae strain ECNIH4

Toxin (Protein)


Gene name - Uniprot ID A0A2J0PLX5
Locus tag ECNIH4_RS15125 Protein ID WP_023337016.1
Coordinates 3170154..3170627 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J0PMR8
Locus tag ECNIH4_RS15120 Protein ID WP_023337017.1
Coordinates 3169714..3170157 (+) Length 148 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECNIH4_RS15105 (ECNIH4_15105) 3165523..3167244 + 1722 WP_014883200.1 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC -
ECNIH4_RS15110 (ECNIH4_15110) 3167290..3167994 + 705 WP_023337019.1 leucyl/phenylalanyl-tRNA--protein transferase -
ECNIH4_RS15115 (ECNIH4_15115) 3168279..3168497 + 219 WP_002211347.1 translation initiation factor IF-1 -
ECNIH4_RS15120 (ECNIH4_15120) 3169714..3170157 + 444 WP_023337017.1 DUF2384 domain-containing protein Antitoxin
ECNIH4_RS15125 (ECNIH4_15125) 3170154..3170627 + 474 WP_023337016.1 RES domain-containing protein Toxin
ECNIH4_RS15130 (ECNIH4_15130) 3170649..3171203 - 555 WP_023337015.1 type I-F CRISPR-associated endoribonuclease Cas6/Csy4 -
ECNIH4_RS15135 (ECNIH4_15135) 3171213..3172211 - 999 WP_038421207.1 type I-F CRISPR-associated protein Csy3 -
ECNIH4_RS15140 (ECNIH4_15140) 3172225..3173160 - 936 WP_023337013.1 type I-F CRISPR-associated protein Csy2 -
ECNIH4_RS15145 (ECNIH4_15145) 3173157..3174179 - 1023 WP_225990831.1 type I-F CRISPR-associated protein Csy1 -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-148)

Antitoxin

(15-147)


Sequences


Toxin        


Download         Length: 158 a.a.        Molecular weight: 17570.82 Da        Isoelectric Point: 5.0700

>T49985 WP_023337016.1 NZ_CP009850:3170154-3170627 [Enterobacter cloacae]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHVRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQANSALALILPSCIIPYENNAILNPLHPSFHTALNSVQQLPFNFDTRLAEKTAP

Download         Length: 474 bp

>T49985 NZ_CP009850:3170154-3170627 [Enterobacter cloacae]
ATGATTTTTTATCGTCTGGTGACAGGGCGCTATGCCAGCGAAGCGTGGAGCGGAAGTGGTGCAAACCAGTATGGCGGGCG
GTGGAATCATAAAGGCCATCCAGCTGTGTATGTGTCCACCTCCATTTCACTGGCCTCACTGGAGATTTTGGTGCACGTTC
GAAAAGATACTGTACTGAATCAGTACCAGCTTTTCAGCATTGATATCCCGGATGACCAGATTGATTACCTGGATAAAGCG
TGGCTCCCCGAGGACTGGCAGGAAAATCCGGCCCCCGTATCAACGATGGATCTGGGAACCGGTTGGTTGCAGGCTAACAG
CGCCCTCGCACTCATCTTACCCTCCTGCATCATTCCTTATGAAAACAATGCCATCCTTAACCCCTTACATCCGTCCTTCC
ACACGGCGCTCAATTCAGTTCAGCAACTGCCCTTTAATTTTGATACCCGCCTGGCTGAAAAAACCGCACCCTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16349.68 Da        Isoelectric Point: 7.2062

>AT49985 WP_023337017.1 NZ_CP009850:3169714-3170157 [Enterobacter cloacae]
MRTWIPAQKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQAPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Download         Length: 444 bp

>AT49985 NZ_CP009850:3169714-3170157 [Enterobacter cloacae]
ATGAGAACATGGATCCCCGCGCAGAAACCTGCTGATAACGCGCTTTGGCGGTACGCCGGTTTACCTGCAAACAGAGGTAT
GCGGCTGATTGAATTTCTCAATCAGGGATTACCCGTCAGCGTCCTCGACAATATCCATGAGTGGACGGCGATGTCGAAAG
CGGACATTTTGCGCGTCACCGGAATTAATGAACGTAACGTGGCCCGGCGCAAAAGCGCGGGACGGACGCTGACGCCGGAT
GAAAGCGAACGCGTGGCCCGTTTCGTTCGGGTGCTGGATGCTGCTGTCGACTATTTTGGCAGTAAAGAAGAGGCATGGAA
CTGGCTGCAGGCACCGGTGCGCGGGCTAGGGAATGTTGCCCCTGTCGACCTGATCGCGACCGAAACCGGTGCACTGGAAG
TCACCGACTTGATTGGTCGACTCGAACATGGTGTGTTCGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2J0PLX5


Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PMR8

References