Detailed information of TA system TA049927

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 925829..926501
• Replicon: chromosome
• Accession: NZ_CP009838
• Organism: Yersinia enterocolitica strain 2516-87

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A7U7FIQ4
• Locus tag: CH48_RS04555
• Protein ID: WP_005166047.1
• Coordinates: 925829..926254 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: CH48_RS04560
• Protein ID: WP_013649338.1
• Coordinates: 926235..926501 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CH48_RS04535	921603..922121	+	519	WP_005166042.1	flavodoxin FldB	-
CH48_RS04540	922180..923601	-	1422	WP_013649341.1	cell envelope integrity protein CreD	-
CH48_RS04545	923693..925120	-	1428	WP_042663699.1	two-component system sensor histidine kinase CreC	-
CH48_RS04550	925131..925829	-	699	WP_005166045.1	two-component system response regulator CreB	-
CH48_RS04555	925829..926254	-	426	WP_005166047.1	protein YgfX	Toxin
CH48_RS04560	926235..926501	-	267	WP_013649338.1	FAD assembly factor SdhE	Antitoxin
CH48_RS04565	926768..927760	+	993	WP_005166051.1	tRNA-modifying protein YgfZ	-
CH48_RS04570	927956..928975	+	1020	WP_020282800.1	IS110 family transposase	-
CH48_RS04575	929387..930070	-	684	WP_013649336.1	hemolysin III family protein	-
CH48_RS04580	930301..930903	+	603	WP_013649335.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	927956..928975	1019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16425.21 Da
• Isoelectric Point: 9.8217

>T49927 WP_005166047.1 NZ_CP009838:c926254-925829 [Yersinia enterocolitica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Nucleotide

• Length: 426 bp

>T49927 NZ_CP009838:c926254-925829 [Yersinia enterocolitica]
GTGGCCCAGTGGCGATGTGACCTGCGGATATCCTGGCACACTCAACTCTTCTCTCTATTAGCTCATGGCGTCCTGGTCAC
ATTAACGCTGGTTGCGCCTTGGCCTCAGGGCTATACCGCACTGTGGTTGGTGCTACTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCTTGCCAAGGTGAGATCAGGCTGAAACCCGGCAATATAGTGCTATGGAAACGGCAT
GAGTGGGTCGTCATTAAGCAGCCGTGGATCACCCGTTATGGCGTATTATTGAGTTTACAACAGACAAGCAGTCGCTCAAC
CCGTAAGCGTTTATGGCTAGCGGCTGATAGCATGTCTGAAGAGGAATGGCGGCAATTGTGTCTCCTGCTGCGCCATTCAT
TTGGCTCCGATGAAGGTATTAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10519.06 Da
• Isoelectric Point: 5.1405

>AT49927 WP_013649338.1 NZ_CP009838:c926501-926235 [Yersinia enterocolitica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KVRGPVAM

Nucleotide

• Length: 267 bp

>AT49927 NZ_CP009838:c926501-926235 [Yersinia enterocolitica]
ATGGAAATCGATAATAAAGCCCGTATTCACTGGGCGTGCCGTCGGGGTATGCGTGAACTGGATATCTCTATCATGCCGTT
TTTTGAACATGAATATGATGGCTTGAGCGATAACGAGAAACAGGTTTTTATCCGTTTGCTTGAGTGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCACGGGGAACCGCAGGATAGTGAGCTGCGTCAAATGGTCAAACTGATTCAAACACGAAAT
AAAGTCCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: A0A7U7FIQ4