Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 122996..123591 Replicon chromosome
Accession NZ_CP009745
Organism Burkholderia contaminans strain MS14

Toxin (Protein)


Gene name chpB Uniprot ID A0A6P2VEG8
Locus tag NL30_RS31475 Protein ID WP_047852791.1
Coordinates 122996..123346 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0G3Z282
Locus tag NL30_RS31480 Protein ID WP_039362633.1
Coordinates 123340..123591 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL30_RS31455 118276..119835 + 1560 WP_047852789.1 efflux transporter outer membrane subunit -
NL30_RS41075 119998..120951 - 954 WP_152034495.1 hypothetical protein -
NL30_RS38110 121000..121392 - 393 WP_053060319.1 hypothetical protein -
NL30_RS38115 121396..121758 - 363 WP_152034496.1 hypothetical protein -
NL30_RS31470 122317..122697 - 381 WP_047852790.1 hypothetical protein -
NL30_RS39845 122775..122984 - 210 WP_081421294.1 hypothetical protein -
NL30_RS31475 122996..123346 - 351 WP_047852791.1 type II toxin-antitoxin system ChpB family toxin Toxin
NL30_RS31480 123340..123591 - 252 WP_039362633.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NL30_RS39850 123760..123954 - 195 Protein_113 tyrosine-type recombinase/integrase -
NL30_RS41080 123959..124228 + 270 Protein_114 RND transporter -
NL30_RS31490 124579..126399 + 1821 WP_047852793.1 asparagine synthase (glutamine-hydrolyzing) -
NL30_RS31495 126640..128100 - 1461 WP_047852794.1 heavy metal sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12389.27 Da        Isoelectric Point: 10.0752

>T49579 WP_047852791.1 NZ_CP009745:c123346-122996 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTVGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGSGTETQGVALV
NMVRTLDLQARGARKVERAPSEVVEDALARLQTILE

Download         Length: 351 bp

>T49579 NZ_CP009745:c123346-122996 [Burkholderia contaminans]
ATGGTGAGGCGCGTCAAGTTCGAGAGGGGCGATATCGTGCGCGTTAGCCTGAACCCCACCGTGGGCAAGGAGCAACAGGG
GGATTTTCGCCCCGCGCTCGTTCTGTCGCCTGCTGCGTTCAATGCGCTTGGCGTGGCGCTCGTCGCGCCGATTACGCAGG
GCGGCGAATTCGCGCGATACGCGGGATTCGCTGTGCCCCTCTCGGGTTCGGGCACTGAAACGCAGGGCGTGGCCCTTGTG
AACATGGTTCGCACGCTCGATCTTCAGGCGCGTGGCGCACGCAAGGTCGAGCGCGCTCCGTCCGAAGTGGTCGAAGATGC
GCTCGCGCGTCTTCAGACCATTCTTGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8948.19 Da        Isoelectric Point: 4.7204

>AT49579 WP_039362633.1 NZ_CP009745:c123591-123340 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIDASVGSSLNADVRPDGVLLSPARRKYSLDELIAQCDPKAPEPADLAAWGESKPVGH
EAW

Download         Length: 252 bp

>AT49579 NZ_CP009745:c123591-123340 [Burkholderia contaminans]
ATGGAACTCAAAATTCAGAAGTGGGGCAACAGCGCCGCAGTCCGGCTTCCGGCCGTGCTGCTTGAGCAAATCGACGCGTC
GGTAGGTAGCTCGCTGAACGCCGATGTGCGCCCCGATGGTGTGTTGCTTTCGCCAGCCCGGCGCAAGTATTCACTGGATG
AACTGATTGCGCAGTGCGATCCGAAGGCCCCGGAACCCGCCGACCTTGCCGCGTGGGGCGAATCCAAGCCGGTGGGGCAT
GAAGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P2VEG8

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3Z282

References