Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1357099..1357740 Replicon chromosome
Accession NZ_CP009744
Organism Burkholderia contaminans strain MS14

Toxin (Protein)


Gene name relE Uniprot ID A0A6P3A5N9
Locus tag NL30_RS21740 Protein ID WP_046549447.1
Coordinates 1357099..1357437 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1J9PWC2
Locus tag NL30_RS21745 Protein ID WP_039344756.1
Coordinates 1357441..1357740 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL30_RS21730 1353664..1355097 - 1434 WP_047851661.1 aldehyde dehydrogenase family protein -
NL30_RS21735 1355127..1356767 - 1641 WP_039344750.1 acetolactate synthase large subunit -
NL30_RS21740 1357099..1357437 + 339 WP_046549447.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL30_RS21745 1357441..1357740 + 300 WP_039344756.1 putative addiction module antidote protein Antitoxin
NL30_RS21750 1357789..1359075 - 1287 WP_047851662.1 DUF445 domain-containing protein -
NL30_RS21755 1359246..1360466 - 1221 WP_047851663.1 FAD-dependent oxidoreductase -
NL30_RS21760 1360456..1360782 - 327 WP_006479527.1 non-heme iron oxygenase ferredoxin subunit -
NL30_RS21765 1360803..1361291 - 489 WP_011355917.1 aromatic-ring-hydroxylating dioxygenase subunit beta -
NL30_RS21770 1361305..1362576 - 1272 WP_039344770.1 Rieske 2Fe-2S domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-107)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12655.53 Da        Isoelectric Point: 8.9480

>T49577 WP_046549447.1 NZ_CP009744:1357099-1357437 [Burkholderia contaminans]
MVDILQSMPYSAPTFSIRTTDVFDTWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMLAHLDME

Download         Length: 339 bp

>T49577 NZ_CP009744:1357099-1357437 [Burkholderia contaminans]
ATGGTTGACATACTGCAATCCATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGACGTCTTCGACACCTGGTT
TGCCGGCCTGCAGGATCGCGTCGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTCTCGATGGGCAATCCGGGCGACT
GGAAGTCCGCCGGCTCGCCGGTCGTCGAGATGCGGATCGACCACGGCCCGGGCTATCGCGTCTACTACGTCCGGCGCGGA
ACGATCTGGGTCATCCTGCTCTGCGGCGGCGATAAATCGACGCAACAGGCCGACATCCGCGCCGCGCACGCGATGCTCGC
GCATCTCGACATGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10649.01 Da        Isoelectric Point: 6.3217

>AT49577 WP_039344756.1 NZ_CP009744:1357441-1357740 [Burkholderia contaminans]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp

>AT49577 NZ_CP009744:1357441-1357740 [Burkholderia contaminans]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGATCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCGCGTGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCCAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P3A5N9

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9PWC2

References