Detailed information of TA system TA049575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 3334604..3335283
• Replicon: chromosome
• Accession: NZ_CP009743
• Organism: Burkholderia contaminans strain MS14

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: NL30_RS14850
• Protein ID: WP_081421109.1
• Coordinates: 3334604..3335020 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A4R4C8B3
• Locus tag: NL30_RS14855
• Protein ID: WP_047850906.1
• Coordinates: 3335017..3335283 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NL30_RS39010	3330912..3331079	-	168	WP_105815830.1	type II toxin-antitoxin system RelE/ParE family toxin	-
NL30_RS14835	3331105..3332268	-	1164	WP_046545689.1	amidohydrolase	-
NL30_RS14840	3332611..3333681	+	1071	WP_046545688.1	hypothetical protein	-
NL30_RS14845	3333650..3334555	+	906	WP_047850905.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
NL30_RS14850	3334604..3335020	-	417	WP_081421109.1	PIN domain-containing protein	Toxin
NL30_RS14855	3335017..3335283	-	267	WP_047850906.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
NL30_RS14860	3335533..3336549	-	1017	WP_046545685.1	acetyltransferase	-
NL30_RS14865	3336549..3337388	-	840	WP_046545684.1	N(5)-hydroxyornithine transformylase PvdF	-
NL30_RS14870	3337475..3339736	-	2262	WP_046545683.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-55)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14557.59 Da
• Isoelectric Point: 6.8603

>T49575 WP_081421109.1 NZ_CP009743:c3335020-3334604 [Burkholderia contaminans]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAVSYAEMRFGAVGGKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADFASRGTPIGTNDASIAGHAIAAGAVLVTHDSREFGRVAGLTLEDWAA

Nucleotide

• Length: 417 bp

>T49575 NZ_CP009743:c3335020-3334604 [Burkholderia contaminans]
GTGACCACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCGCCCGTGGTGCTGTCCCGGTT
GCAGTCGTGCGTCAATGCGCAACACCGGATCGTCGTCTCGGCAGTTAGCTATGCCGAAATGCGCTTCGGCGCGGTCGGCG
GGAAGGCATCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTTTCGCGACTGGATGGCGTGCTGTCGTGGGACACGGCG
GCCGTCGACGCAACGGCCGCGATTCGTGCGGATTTCGCCTCGCGCGGCACGCCGATCGGCACCAACGACGCATCGATCGC
GGGCCATGCGATTGCGGCCGGTGCGGTGCTCGTCACCCACGACAGCCGCGAGTTCGGCCGTGTCGCCGGGTTGACGCTCG
AAGACTGGGCGGCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9728.94 Da
• Isoelectric Point: 4.4819

>AT49575 WP_047850906.1 NZ_CP009743:c3335283-3335017 [Burkholderia contaminans]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPPADADFLAERPSVIEPGRFDLSDGGG
AAPTESGQ

Nucleotide

• Length: 267 bp

>AT49575 NZ_CP009743:c3335283-3335017 [Burkholderia contaminans]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGGGTGAC
CGAACTCGAGATTCGCCGCGAGGGCGACACACTGCTGCTGCGGCCGGTGCGGCCCACATGGCTCTCGTTCGCGAGCGAAC
CGCCGGCCGACGCCGACTTCCTTGCCGAACGCCCGTCCGTCATCGAGCCCGGCCGCTTCGACCTGTCCGACGGTGGCGGC
GCCGCACCGACGGAGTCCGGCCAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4R4C8B3