Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 652898..654648 Replicon chromosome
Accession NZ_CP009743
Organism Burkholderia contaminans strain MS14

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NL30_RS02820 Protein ID WP_047849730.1
Coordinates 652898..653794 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4R4BXQ4
Locus tag NL30_RS02825 Protein ID WP_047849731.1
Coordinates 653791..654648 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL30_RS02790 648268..649347 - 1080 WP_047849727.1 porin -
NL30_RS02795 649792..650109 + 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
NL30_RS02800 650111..650422 + 312 WP_047849728.1 hypothetical protein -
NL30_RS02805 650475..651551 + 1077 WP_047849729.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NL30_RS02810 651544..652314 + 771 WP_046548149.1 SDR family oxidoreductase -
NL30_RS02815 652352..652879 + 528 WP_039344094.1 cupin domain-containing protein -
NL30_RS02820 652898..653794 + 897 WP_047849730.1 alpha/beta fold hydrolase Toxin
NL30_RS02825 653791..654648 + 858 WP_047849731.1 IclR family transcriptional regulator Antitoxin
NL30_RS02830 654645..655442 + 798 WP_047849732.1 SDR family oxidoreductase -
NL30_RS02835 655435..657102 + 1668 WP_047849733.1 thiamine pyrophosphate-binding protein -
NL30_RS02840 657095..657922 + 828 WP_047849734.1 aspartate dehydrogenase -
NL30_RS02845 657995..659485 + 1491 WP_039344105.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30786.11 Da        Isoelectric Point: 8.3600

>T49574 WP_047849730.1 NZ_CP009743:652898-653794 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPERRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLMSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERVAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp

>T49574 NZ_CP009743:652898-653794 [Burkholderia contaminans]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTCCCCGAACGGCGTTG
CGCGGCCGGCGCTGCGGGCACGATCGGATATCGCGAGGCCGGCGCGCACCATGCGGGCCGTGCGTTGCCCGTCGTGCTGC
TGCACGGCATCGGCTCGGGCGCCGCATCGTGGGTGCGCCAGCTCGACACGCTCGGCGCATCGCGGCGCGTGCTCGCGTGG
GATGCGCCCGGTTACGGCGTGTCGACGCCGGTGCACGGCGCGTCGCCGGCCGCCACCGATTACGCGGCATCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGATCATCGCGGGTGGTCTCATCC
GCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATGTCGCCCGCGGGCGGCTACGGCAGCGCACCGGCCGAAACGCGC
GACGCGCGCCGCGACGCGCGGCTCGCGATGCTCGCCGAACTCGGCCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCCGGTTTCGCGAACGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGC
AGGCCACGCATCTGCTGGCGAACGCCGATCTCGCAACGGATCTCGCGGGCTTTCGCGGCCGGACGGCCGTGGCCGTCGGC
GCGAATGACGCGATCACGCCGCCCGCCGCGTGCGAGCGCGTCGCCGCGGCCGCGCACGTCGGGCTGCAGGTGATTCCGCA
GGCAGGCCATGCCGGCTACGTAGAAGCACCGGCCGTCTATTCCGCACTGATCGACACGTTCTGCCGTCAGTGCGACCAAC
AGCGGGGACTGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31404.94 Da        Isoelectric Point: 6.5061

>AT49574 WP_047849731.1 NZ_CP009743:653791-654648 [Burkholderia contaminans]
MNEPLQQPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT49574 NZ_CP009743:653791-654648 [Burkholderia contaminans]
ATGAACGAACCGCTGCAACAACCCGAACTCGAAAACGGCAAGGCCGAAGCCAGCTACGTGGTGCCCGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAATTGTCGAAGCGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTCCTCGAGCGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATTGCCGTGCTGCGGCTCGGTTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCCGTGATCGA
AAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGTGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGGCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACGCGCTTGCCCGCGCATGCGACGACGCACGGTCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCATGCGCTATATCCGGAAGGCGCGCTGAACCGGATGACGAACGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGTAACGAGACGCAGAGGATCGTTGCGTGCATCACGGTGACGGTGCCG
AGGCCGGAAATCGACGCGGCGCTGATCGCGGACGGCCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTTTGAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4BXQ4

References