Detailed information of TA system TA049519

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2117392..2118086
• Replicon: chromosome
• Accession: NZ_CP009715
• Organism: Yersinia pestis Pestoides F

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0E1NW62
• Locus tag: BZ18_RS10840
• Protein ID: WP_002214787.1
• Coordinates: 2117392..2117688 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: BZ18_RS10845
• Protein ID: WP_002209924.1
• Coordinates: 2117688..2118086 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BZ18_RS10805	2112514..2114031	+	1518	WP_002209930.1	lysine--tRNA ligase	-
BZ18_RS10815	2114464..2115678	+	1215	WP_011906175.1	tyrosine-type recombinase/integrase	-
BZ18_RS10820	2115760..2115945	-	186	WP_002209928.1	hypothetical protein	-
BZ18_RS10830	2116543..2116803	+	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BZ18_RS10835	2116866..2117228	+	363	WP_002209925.1	helix-turn-helix domain-containing protein	-
BZ18_RS10840	2117392..2117688	+	297	WP_002214787.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BZ18_RS10845	2117688..2118086	+	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BZ18_RS10850	2118486..2120777	-	2292	WP_002209923.1	toprim domain-containing protein	-
BZ18_RS10855	2121077..2121403	+	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BZ18_RS24605	2121396..2121548	+	153	WP_002209921.1	hypothetical protein	-
BZ18_RS10865	2121562..2121762	-	201	WP_002209920.1	AlpA family transcriptional regulator	-
BZ18_RS10870	2121944..2122276	-	333	WP_002214791.1	hypothetical protein	-
BZ18_RS10875	2122282..2122518	-	237	WP_002214792.1	hypothetical protein	-
BZ18_RS10880	2122531..2122896	-	366	WP_002209919.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11319.12 Da
• Isoelectric Point: 7.8810

>T49519 WP_002214787.1 NZ_CP009715:2117392-2117688 [Yersinia pestis Pestoides F]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Nucleotide

• Length: 297 bp

>T49519 NZ_CP009715:2117392-2117688 [Yersinia pestis Pestoides F]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT49519 WP_002209924.1 NZ_CP009715:2117688-2118086 [Yersinia pestis Pestoides F]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT49519 NZ_CP009715:2117688-2118086 [Yersinia pestis Pestoides F]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Toxin

• AlphaFold DB: A0A0E1NW62

Antitoxin

• AlphaFold DB: Q666X1