Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3703023..3703738 Replicon chromosome
Accession NZ_CP009706
Organism Hafnia alvei FB1

Toxin (Protein)


Gene name ypjF Uniprot ID A0A097R5C8
Locus tag AT03_RS17075 Protein ID WP_025800135.1
Coordinates 3703023..3703391 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A097R5D9
Locus tag AT03_RS17080 Protein ID WP_025800137.1
Coordinates 3703412..3703738 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AT03_RS17050 3698819..3699169 - 351 WP_025800127.1 transcriptional regulator -
AT03_RS22055 3700819..3701011 - 193 Protein_3322 hypothetical protein -
AT03_RS17060 3701333..3701671 - 339 WP_025800130.1 hypothetical protein -
AT03_RS17065 3701674..3702537 - 864 WP_025800131.1 glucosaminidase domain-containing protein -
AT03_RS17075 3703023..3703391 - 369 WP_025800135.1 TA system toxin CbtA family protein Toxin
AT03_RS17080 3703412..3703738 - 327 WP_025800137.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
AT03_RS17085 3703849..3704562 - 714 Protein_3327 DUF945 domain-containing protein -
AT03_RS22430 3705823..3705927 - 105 Protein_3329 DUF945 domain-containing protein -
AT03_RS17100 3706077..3706874 - 798 WP_025800141.1 hypothetical protein -
AT03_RS17105 3707317..3708201 - 885 WP_025800143.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3701333..3719909 18576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13724.96 Da        Isoelectric Point: 7.2641

>T49496 WP_025800135.1 NZ_CP009706:c3703391-3703023 [Hafnia alvei FB1]
MNTLPVIIPQAAKQCLPPVTVWQMLLTRLLEQHYGLTLHDTPFSDEAVIQEHIDAGITLANAVNFLVEKYELVRIDRCGF
SSQVQAPYLTATDILHARKACGLMSRCSYREVSNIVLSRSRL

Download         Length: 369 bp

>T49496 NZ_CP009706:c3703391-3703023 [Hafnia alvei FB1]
ATGAATACTCTACCTGTAATCATCCCACAGGCGGCGAAGCAATGTCTGCCGCCCGTAACTGTCTGGCAAATGTTACTTAC
TCGCCTGCTTGAACAGCACTATGGTCTGACGCTACACGACACACCTTTTAGTGATGAAGCCGTCATACAGGAACATATCG
ATGCTGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTGGAGAAGTATGAGTTAGTCCGCATCGATCGCTGTGGATTT
TCCTCACAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCATGCCAGGAAAGCGTGCGGGCTGATGAGTCGGTG
TTCTTACAGGGAGGTAAGTAATATTGTTCTTAGCCGATCACGGCTGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12163.87 Da        Isoelectric Point: 6.4767

>AT49496 WP_025800137.1 NZ_CP009706:c3703738-3703412 [Hafnia alvei FB1]
MSLIPAHEWGLKSDIVRRFGARLVQEGNRLHYLADRAGLMGMSSDTECLKLEEAFPHFISQMESILTTGELNSRHAHCVT
LYHNGFTCEADTLGSCGYVYIVVYPTQR

Download         Length: 327 bp

>AT49496 NZ_CP009706:c3703738-3703412 [Hafnia alvei FB1]
ATGTCATTAATACCAGCCCATGAATGGGGGCTAAAAAGCGATATTGTTCGACGGTTTGGTGCCAGATTAGTTCAGGAAGG
CAACCGGCTACATTACCTGGCAGACAGGGCTGGGTTGATGGGAATGTCCAGCGATACCGAATGTCTTAAACTAGAGGAAG
CATTTCCGCACTTTATCAGTCAGATGGAATCAATTTTGACCACTGGCGAGCTGAATTCCCGCCATGCCCATTGCGTCACC
CTGTACCACAACGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTTTACATCGTCGTCTATCCCACTCA
ACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097R5C8

Antitoxin

Source ID Structure
AlphaFold DB A0A097R5D9

References