Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3194078..3194661 Replicon chromosome
Accession NZ_CP009553
Organism Pandoraea pnomenusa strain DSM 16536

Toxin (Protein)


Gene name hicA Uniprot ID A0A378YZZ9
Locus tag LV28_RS38255 Protein ID WP_038620832.1
Coordinates 3194078..3194269 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A378YZS0
Locus tag LV28_RS38260 Protein ID WP_038620831.1
Coordinates 3194266..3194661 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LV28_RS38235 3190095..3191348 - 1254 WP_115344660.1 terminase family protein -
LV28_RS38240 3191362..3191844 - 483 WP_115344510.1 hypothetical protein -
LV28_RS38245 3191978..3193351 - 1374 WP_038620835.1 chromosome partitioning protein ParB -
LV28_RS38250 3193491..3193841 + 351 WP_058371660.1 hypothetical protein -
LV28_RS38255 3194078..3194269 + 192 WP_038620832.1 type II toxin-antitoxin system HicA family toxin Toxin
LV28_RS38260 3194266..3194661 + 396 WP_038620831.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LV28_RS38265 3194684..3194935 + 252 WP_038620829.1 hypothetical protein -
LV28_RS38270 3195037..3195663 - 627 WP_048806609.1 hypothetical protein -
LV28_RS38275 3195696..3196166 - 471 WP_038622431.1 RusA family crossover junction endodeoxyribonuclease -
LV28_RS38280 3196163..3196366 - 204 WP_058371661.1 hypothetical protein -
LV28_RS38285 3196369..3197145 - 777 WP_048806608.1 hypothetical protein -
LV28_RS48395 3197096..3198007 - 912 WP_081326897.1 YdaU family protein -
LV28_RS38295 3198004..3198483 - 480 WP_038620828.1 hypothetical protein -
LV28_RS38300 3198485..3198895 - 411 WP_145929451.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3169601..3215368 45767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-124)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7126.24 Da        Isoelectric Point: 11.3261

>T49260 WP_038620832.1 NZ_CP009553:3194078-3194269 [Pandoraea pnomenusa]
MTSADIIKRLKAAGFTEVSVRGSHHKFRHENGRVVIVPHPKKDMPIGTTRSIFKQAGIDWRSE

Download         Length: 192 bp

>T49260 NZ_CP009553:3194078-3194269 [Pandoraea pnomenusa]
ATGACAAGCGCAGACATCATCAAACGACTGAAGGCCGCCGGGTTCACCGAAGTGTCGGTGCGAGGCAGCCACCACAAATT
CCGGCACGAGAACGGTCGCGTGGTGATCGTCCCGCACCCGAAGAAGGACATGCCGATAGGCACCACCCGCTCGATCTTCA
AGCAAGCGGGCATTGACTGGAGAAGCGAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14774.59 Da        Isoelectric Point: 4.2687

>AT49260 WP_038620831.1 NZ_CP009553:3194266-3194661 [Pandoraea pnomenusa]
MKYPIYVWQEGDSAFGATFPDLPGVHTAADTLDDLERMAQEAVELMYEDSDEQIPAPTYDIKKLHANEVDDGTGFWMFVE
IDLSKISSKAVRLNISLPERLVSQIDAEAEKRHMSRSAFLALAAQREMEHA

Download         Length: 396 bp

>AT49260 NZ_CP009553:3194266-3194661 [Pandoraea pnomenusa]
ATGAAATATCCGATCTACGTGTGGCAAGAAGGCGATAGCGCCTTCGGCGCCACGTTCCCGGATCTTCCGGGCGTGCACAC
TGCAGCGGATACGCTCGACGACCTTGAGCGTATGGCACAGGAGGCGGTCGAGCTCATGTACGAAGACAGCGACGAGCAGA
TCCCGGCGCCGACATACGACATCAAGAAGCTGCACGCGAATGAAGTCGACGACGGCACTGGCTTCTGGATGTTCGTGGAA
ATCGACCTGTCAAAAATCAGCAGCAAGGCTGTTCGATTGAATATCAGCCTGCCGGAGCGCCTCGTGAGCCAGATTGATGC
GGAAGCCGAGAAGCGCCATATGTCGCGCTCGGCATTTCTGGCACTCGCGGCACAGCGCGAGATGGAACACGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378YZZ9

Antitoxin

Source ID Structure
AlphaFold DB A0A378YZS0

References