Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 840628..842471 Replicon chromosome
Accession NZ_CP009322
Organism Burkholderia gladioli strain ATCC 10248

Toxin (Protein)


Gene name doc Uniprot ID A0A808W4K9
Locus tag BM43_RS04455 Protein ID WP_036057353.1
Coordinates 840628..841593 (+) Length 322 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BM43_RS04460 Protein ID WP_042285493.1
Coordinates 841611..842471 (+) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM43_RS04425 835936..837015 - 1080 WP_017921239.1 porin -
BM43_RS04430 837430..837747 + 318 WP_013689902.1 non-heme iron oxygenase ferredoxin subunit -
BM43_RS04435 837750..838061 + 312 WP_025097963.1 hypothetical protein -
BM43_RS04440 838103..839212 + 1110 WP_025097964.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BM43_RS04445 839205..839975 + 771 WP_036056699.1 SDR family oxidoreductase -
BM43_RS04450 840074..840601 + 528 WP_036038832.1 cupin domain-containing protein -
BM43_RS04455 840628..841593 + 966 WP_036057353.1 alpha/beta fold hydrolase Toxin
BM43_RS04460 841611..842471 + 861 WP_042285493.1 IclR family transcriptional regulator Antitoxin
BM43_RS04465 842468..843265 + 798 WP_013689909.1 SDR family oxidoreductase -
BM43_RS04470 843258..844931 + 1674 WP_036056697.1 thiamine pyrophosphate-binding protein -
BM43_RS04475 844924..845757 + 834 WP_036056696.1 aspartate dehydrogenase -
BM43_RS04480 845834..847324 + 1491 WP_036056695.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(66-304)

Antitoxin

Transcription regulator IclR, N-terminal

(25-73)


Sequences

Toxin        


Download         Length: 322 a.a.        Molecular weight: 32867.37 Da        Isoelectric Point: 7.3751

>T48764 WP_036057353.1 NZ_CP009322:840628-841593 [Burkholderia gladioli]
MSEIDPRGAEAEAGPDAALAARLWQFPARRIAIREAGLIGWRESGPAQGAGDSTARAAAGERALPVVLLHGIGSGAASWL
AQLDTLGASRRVLAWDAPGYGESTPVAPASPLAADYAASLAGWLDALAIERCVLVGHSLGAIVAGAFARRHAGRLAGLLL
VSPAAGYGAAPAATRDERRDARLAMLAALGPAGLAEQRSANMLSAHAGEAARAWVRRVMAQVKPAGYTQATHLLANADLA
ADLAAWRAMTDAAGAARVEVMVGAEDGITPPNACERIAAAAGVALRIVPRAGHAGYVEAPERYSALIGAFCARCDESWRQ
A

Download         Length: 966 bp

>T48764 NZ_CP009322:840628-841593 [Burkholderia gladioli]
ATGAGCGAAATCGATCCGCGCGGGGCCGAGGCAGAGGCTGGGCCCGACGCGGCCCTGGCCGCCCGACTCTGGCAGTTTCC
GGCGCGGCGCATCGCCATTCGCGAAGCCGGGCTGATCGGCTGGCGCGAATCGGGTCCAGCGCAGGGGGCCGGCGATTCGA
CGGCACGCGCGGCCGCTGGCGAGCGGGCATTGCCGGTGGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCCTCGTGGCTG
GCCCAGCTCGACACGCTCGGCGCGTCGCGTCGCGTGCTGGCCTGGGACGCGCCCGGTTATGGCGAATCGACGCCGGTCGC
GCCGGCCTCGCCGCTGGCGGCCGATTACGCGGCGTCGCTGGCCGGCTGGCTCGACGCGCTCGCCATCGAGCGCTGCGTGC
TGGTGGGGCACTCGCTCGGCGCGATCGTGGCCGGCGCCTTCGCGCGCCGGCATGCCGGGCGGCTGGCCGGCTTGCTGCTG
GTTTCGCCGGCCGCCGGCTACGGCGCGGCACCGGCCGCCACGCGCGACGAACGGCGCGATGCGCGGCTCGCGATGCTGGC
CGCGCTCGGGCCCGCGGGCCTGGCCGAACAACGCAGCGCCAACATGCTGTCGGCGCATGCCGGCGAGGCCGCCCGCGCCT
GGGTGCGCCGCGTGATGGCGCAGGTGAAGCCGGCCGGCTACACGCAGGCCACCCACCTGCTCGCGAACGCCGACCTGGCC
GCCGATCTCGCCGCCTGGCGGGCGATGACCGACGCCGCCGGTGCCGCGCGCGTGGAGGTGATGGTGGGCGCCGAGGACGG
CATCACGCCGCCGAACGCCTGCGAACGGATCGCGGCGGCGGCCGGCGTGGCGCTGCGTATCGTGCCGCGCGCCGGCCATG
CCGGCTACGTGGAGGCACCCGAGCGCTACTCGGCGCTGATCGGCGCGTTCTGCGCGCGCTGCGACGAATCATGGAGACAG
GCATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31033.35 Da        Isoelectric Point: 6.5132

>AT48764 WP_042285493.1 NZ_CP009322:841611-842471 [Burkholderia gladioli]
MRSEPADSGAPEADAANGAYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNY
RLGVAVLRLGFEYLSSLELTDLGLPVIEGLREATGFTTHIVIRDGRDVVFVAKAQSAAPAFSSIRVNVGTRLPAHATTHG
HVLMGDLSEAELRALYPERQLERATRATPDSLEALLALVREDAARGYGISNASFERGISVVTAPVRNDTQRIVAAVTVTV
PKPEIDAALIADGLVEKVVRAANELSRRLNYRSDDENSYLKALGLR

Download         Length: 861 bp

>AT48764 NZ_CP009322:841611-842471 [Burkholderia gladioli]
CTGCGAAGCGAGCCGGCCGACAGCGGCGCGCCCGAGGCGGATGCCGCGAACGGCGCCTACGTGGTACCTGGCCTCGAACG
CGGGCTGCGGATCCTCGCGGAATTCTCGCCGCGCGAGCCGGTGCTGGGCGCGCCGGAATTGTCGAAGCGGCTCGGCATTC
CGCGCACCACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTGGGCTTCCTGGAGCGCGCCGACAAGGACCGCAATTAC
CGGCTCGGCGTGGCGGTGCTGCGCCTGGGCTTCGAATACTTGAGCTCGCTGGAGCTGACCGACCTGGGCCTGCCGGTGAT
CGAGGGCCTGCGCGAGGCGACCGGCTTCACCACCCATATCGTGATCCGCGACGGGCGCGACGTGGTGTTCGTCGCCAAGG
CGCAGAGCGCGGCGCCGGCCTTCAGCTCGATTCGCGTCAACGTCGGCACGCGGCTGCCCGCGCATGCCACTACCCACGGC
CACGTGCTGATGGGCGACCTGAGCGAGGCCGAGCTGCGCGCACTGTACCCCGAGCGCCAGCTCGAACGGGCCACGCGTGC
CACGCCCGACAGCCTGGAGGCGCTGCTCGCGCTGGTCCGCGAGGATGCCGCGCGCGGCTACGGCATCAGCAACGCCTCGT
TCGAGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGCAACGACACGCAGCGCATCGTGGCGGCCGTCACGGTGACGGTG
CCGAAACCCGAGATCGACGCGGCGCTGATCGCCGACGGCCTGGTCGAGAAGGTCGTGAGGGCGGCCAATGAACTGTCGCG
GCGGCTCAATTACCGCTCCGATGATGAGAACTCCTATCTGAAGGCATTGGGATTGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808W4K9

Antitoxin

Source ID Structure

References