Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1775704..1776294 Replicon chromosome
Accession NZ_CP009274
Organism Klebsiella variicola strain DX120E

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag KR75_RS08365 Protein ID WP_039104087.1
Coordinates 1775962..1776294 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag KR75_RS08360 Protein ID WP_039104089.1
Coordinates 1775704..1775961 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KR75_RS08340 1771313..1771888 + 576 WP_016161434.1 hypothetical protein -
KR75_RS08345 1772065..1772901 + 837 WP_008804155.1 alpha/beta hydrolase -
KR75_RS08350 1773108..1774079 + 972 WP_016161433.1 sensor domain-containing diguanylate cyclase -
KR75_RS08355 1774076..1775176 - 1101 WP_039104091.1 phosphotransferase -
KR75_RS08360 1775704..1775961 + 258 WP_039104089.1 antitoxin Antitoxin
KR75_RS08365 1775962..1776294 + 333 WP_039104087.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KR75_RS08375 1776617..1778053 + 1437 WP_016161429.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
KR75_RS08385 1778426..1779880 - 1455 WP_008804170.1 AMP nucleosidase -
KR75_RS08390 1780011..1780256 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11895.77 Da        Isoelectric Point: 10.1839

>T48712 WP_039104087.1 NZ_CP009274:1775962-1776294 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAIINEVLARLDAILS

Download         Length: 333 bp

>T48712 NZ_CP009274:1775962-1776294 [Klebsiella variicola]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTCCTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGGCTACCGGTCGTGGTTCCCGTCACCAGCGGCGGAAACTTTGCACGTA
CAGCAGGCTTCACGGTTTCACTGGAAGAGGCGGGGACCAAAACAACAGGCGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCATTATCAATGAAGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9432.97 Da        Isoelectric Point: 4.4915

>AT48712 WP_039104089.1 NZ_CP009274:1775704-1775961 [Klebsiella variicola]
MYKTRLKKVGGSIMLAVPPAVLKALELSIDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT48712 NZ_CP009274:1775704-1775961 [Klebsiella variicola]
ATGTACAAAACTCGCCTGAAAAAGGTTGGCGGATCCATCATGCTGGCGGTTCCTCCCGCCGTGCTGAAAGCGCTGGAGCT
GTCGATAGACAGCGAAGTGGGTATGACTATAGATAATGGCTGCCTGATTATTGAACCGCAGAAACGGCCCCATTATTCGC
TTGAGGAACTGTTGGCGCAGTGCGATCCGCACGCCGAAATGAGCGAAGAGGATCGGGAATGGATTGATGCGCCTGCGGTG
GGCAAGGAGATTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References