Detailed information of TA system TA048648

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2314560..2316196
• Replicon: chromosome
• Accession: NZ_CP009256
• Organism: Acinetobacter baumannii strain AB31

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A858S2C4
• Locus tag: IX88_RS10855
• Protein ID: WP_031379782.1
• Coordinates: 2314865..2316196 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IX88_RS10850
• Protein ID: WP_001101310.1
• Coordinates: 2314560..2314868 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IX88_RS10820	2309571..2310407	+	837	WP_032000325.1	SDR family NAD(P)-dependent oxidoreductase	-
IX88_RS10825	2310491..2311273	-	783	WP_032000324.1	HNH endonuclease	-
IX88_RS10830	2311479..2311997	-	519	WP_032000323.1	GNAT family N-acetyltransferase	-
IX88_RS10835	2312091..2312507	-	417	WP_032000322.1	hypothetical protein	-
IX88_RS10840	2312570..2313196	-	627	WP_032000320.1	hypothetical protein	-
IX88_RS10845	2313269..2313835	-	567	WP_032000319.1	TetR/AcrR family transcriptional regulator	-
IX88_RS10850	2314560..2314868	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
IX88_RS10855	2314865..2316196	-	1332	WP_031379782.1	type II toxin-antitoxin system HipA family toxin	Toxin
IX88_RS10860	2316492..2316932	+	441	WP_002126884.1	HD domain-containing protein	-
IX88_RS10865	2316967..2317611	-	645	WP_032000318.1	hypothetical protein	-
IX88_RS10870	2317623..2318594	-	972	WP_111818113.1	5'/3'-nucleotidase SurE	-
IX88_RS10875	2318721..2319884	-	1164	WP_032000316.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51202.34 Da
• Isoelectric Point: 4.9820

>T48648 WP_031379782.1 NZ_CP009256:c2316196-2314865 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T48648 NZ_CP009256:c2316196-2314865 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAGGCTTTACTAAATAAAAACTGGATAGATATAGCAGAACTAAAACTGCTGGAACCTAAGTT
GGGTTCGGCTAGCGCCAGTGAACTAGAGTATGAGTTGAATTATGCCATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACATGAATCGGACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTGGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCTATT
AGTGGTGGTGCAACTGGTGCTGGCGGGGAAGCTCCCAAATTACTTATTCGTGTTTCACCGGAACAAAAAGTCTGGATTGA
CACCTACCAAGAAAAATTTGATCAGCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAAACGTAGCGAGATTGATT
GTGACATTCTGAGAGCCGAATATTATTATTATCAGATACTCAATGAATTAGGTTTCAACACAATTGAAACAACCCAAATG
AAGCTCATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTATTTGTGAGTGGTTACAACGTGACTTACTC
AATATCATTTTTGGCAATTCAGATAACCACGGTCGTAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTACGAGGAAG
GAGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCAACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCAAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT48648 WP_001101310.1 NZ_CP009256:c2314868-2314560 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT48648 NZ_CP009256:c2314868-2314560 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTGTCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Structures

Toxin

• AlphaFold DB: A0A858S2C4