Detailed information of TA system TA048428

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 5935730..5936244
• Replicon: chromosome
• Accession: NZ_CP009124
• Organism: Streptomyces lividans TK24

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: Q9Z4V8
• Locus tag: SLIV_RS26540
• Protein ID: WP_003976577.1
• Coordinates: 5935730..5935984 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q9Z4V7
• Locus tag: SLIV_RS26545
• Protein ID: WP_003976578.1
• Coordinates: 5935981..5936244 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SLIV_RS26520	5932054..5932722	+	669	WP_003976573.1	DUF3105 domain-containing protein	-
SLIV_RS26525	5932719..5933345	+	627	WP_011028217.1	DUF305 domain-containing protein	-
SLIV_RS26530	5933429..5935198	+	1770	WP_037666705.1	NAD+ synthase	-
SLIV_RS26535	5935221..5935667	-	447	WP_003976576.1	VOC family protein	-
SLIV_RS26540	5935730..5935984	-	255	WP_003976577.1	Txe/YoeB family addiction module toxin	Toxin
SLIV_RS26545	5935981..5936244	-	264	WP_003976578.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SLIV_RS26550	5936418..5939417	+	3000	WP_003976579.1	bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase	-
SLIV_RS26555	5939543..5940412	-	870	WP_003976581.1	phosphatase PAP2 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9954.26 Da
• Isoelectric Point: 9.7377

>T48428 WP_003976577.1 NZ_CP009124:c5935984-5935730 [Streptomyces lividans TK24]
VRITFTSHGWEDYVHWAESDRKVTKRINRLIADIARDPFKGVGKPEPLKGDLSGYWSRRIDDTHRLVYKPTDDQLVIVQA
RYHY

Nucleotide

• Length: 255 bp

>T48428 NZ_CP009124:c5935984-5935730 [Streptomyces lividans TK24]
GTGAGGATCACTTTCACGTCCCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCGCCGACATCGCCCGTGACCCGTTCAAGGGCGTCGGCAAGCCGGAGCCGCTCAAGGGCGACCTGTCCG
GCTACTGGTCACGGCGCATCGACGACACGCACCGTCTTGTGTACAAGCCCACCGATGACCAGCTGGTCATCGTCCAGGCG
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9692.69 Da
• Isoelectric Point: 4.4149

>AT48428 WP_003976578.1 NZ_CP009124:c5936244-5935981 [Streptomyces lividans TK24]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNARRLLDSIAEAEAGDATEHDLI
DPDAERA

Nucleotide

• Length: 264 bp

>AT48428 NZ_CP009124:c5936244-5935981 [Streptomyces lividans TK24]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTCATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCATCTCCTGC
GCTCGCCGAGGAACGCCCGCCGTCTGCTCGACTCCATCGCGGAGGCCGAGGCGGGCGACGCGACTGAGCACGACCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Structures

Toxin

• AlphaFold DB: Q9Z4V8

Antitoxin

• AlphaFold DB: Q9Z4V7