Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1404458..1405311 Replicon chromosome
Accession NZ_CP008885
Organism Bifidobacterium longum strain BXY01

Toxin (Protein)


Gene name relE Uniprot ID D6ZUU6
Locus tag GS08_RS06060 Protein ID WP_013140895.1
Coordinates 1404458..1404949 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6XX41
Locus tag GS08_RS06065 Protein ID WP_008783109.1
Coordinates 1404949..1405311 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS08_RS06045 1400196..1401098 - 903 WP_013140890.1 Bax inhibitor-1/YccA family protein -
GS08_RS10860 1401382..1401522 + 141 Protein_1182 DNA-binding response regulator -
GS08_RS06050 1401563..1402204 + 642 WP_013140893.1 GNAT family N-acetyltransferase -
GS08_RS06055 1402293..1404398 + 2106 WP_013140894.1 DUF262 domain-containing protein -
GS08_RS06060 1404458..1404949 - 492 WP_013140895.1 PIN domain-containing protein Toxin
GS08_RS06065 1404949..1405311 - 363 WP_008783109.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GS08_RS06070 1405457..1408156 - 2700 WP_013140896.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18314.88 Da        Isoelectric Point: 4.5590

>T47846 WP_013140895.1 NZ_CP008885:c1404949-1404458 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T47846 NZ_CP008885:c1404949-1404458 [Bifidobacterium longum]
ATGACCGACGTTTCCATGCAGCGTATTTTGCTCGATACCAACGTACTGTTGGACTATTTGCTCCATCGTGATGATCACGC
CAAGATGGCGGAAGCGGTTATGGAACTTGGCGCGAAGAACAACGTTACGTTGTTGTGCGCGTCACTGTCGCTGAAGGATA
TCGCATACCTATCATCATCGGCGATTCGTAGGGAATTCAAACCGAATGAATCGGAAGTGGAGAATTTCACTCGCGGCTTT
CTGTCGTCACGGGTGCCATGGCGTTGTATCGAGCAGGTGAAGGAGATGTGTGACATTGTCGCTGTCGATGAGTCGACATG
TGATAAGGCTTTTTCCCTGCAAAAACGGCATCGGGATTTTGAAGATGATCTGATCATCGTTGCCGCGCAACAATCCGGTG
CCAACTGTGTGGTCACATCGGATGCCGAACTAATCAGTCATTTTCCCGAATATTGCAAAACACCGGCTGAAATCGTGGCG
GCACTGGAATAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13974.03 Da        Isoelectric Point: 5.0733

>AT47846 WP_008783109.1 NZ_CP008885:c1405311-1404949 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Download         Length: 363 bp

>AT47846 NZ_CP008885:c1405311-1404949 [Bifidobacterium longum]
ATGACCATGGTCCAAATGAACGTTCGCATTGATGCGAAACTGAAGAACGAGGTCGAAGAAGTCCTCAAGGGCAAAGGCGT
ATCGGTAAGTGACGTAATCCGGTCGCTGTGGTTGTACATCGCCGACCGCAAGGAAGTGCCGGCATTGGAAACGACCGCCG
AAGAGCAAGCCCGCGAGGAGGAAAAGCAGCGCAAGCTGAAACTGATTCGAGAAGGTGCCGGATACGTGCACAAGGAACTG
GTCAAGGCCGGACTGATCTCAGAAGACACCGACCTCATGGAAGGCCTTACCTACAAGCAGTTCCGCGACAAAATGTACGA
CGAGCAACTTGATGCGTATTACAACATGAAGAGGGCCGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A564VMG8

Antitoxin

Source ID Structure
AlphaFold DB V6XX41

References