Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 986457..987012 Replicon chromosome
Accession NZ_CP008885
Organism Bifidobacterium longum strain BXY01

Toxin (Protein)


Gene name mazF Uniprot ID D6ZTS1
Locus tag GS08_RS04110 Protein ID WP_013140587.1
Coordinates 986457..986780 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID D6ZTS2
Locus tag GS08_RS04115 Protein ID WP_013140588.1
Coordinates 986767..987012 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS08_RS04090 982533..983798 - 1266 WP_050569334.1 Fic family protein -
GS08_RS04095 984341..984706 - 366 WP_013140585.1 YccF domain-containing protein -
GS08_RS04100 984944..985519 + 576 Protein_801 class I SAM-dependent methyltransferase -
GS08_RS10660 985626..986240 + 615 WP_003829107.1 cupin domain-containing protein -
GS08_RS04110 986457..986780 - 324 WP_013140587.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GS08_RS04115 986767..987012 - 246 WP_013140588.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GS08_RS04120 987183..988439 + 1257 WP_003829116.1 HipA domain-containing protein -
GS08_RS04125 988862..990133 - 1272 WP_013140589.1 MFS transporter -
GS08_RS04130 990290..990952 - 663 WP_038426133.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11801.59 Da        Isoelectric Point: 6.2932

>T47843 WP_013140587.1 NZ_CP008885:c986780-986457 [Bifidobacterium longum]
MKRGEIRTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVADDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

>T47843 NZ_CP008885:c986780-986457 [Bifidobacterium longum]
ATGAAACGAGGTGAGATTCGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCGGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGCT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGCTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9293.39 Da        Isoelectric Point: 4.7719

>AT47843 WP_013140588.1 NZ_CP008885:c987012-986767 [Bifidobacterium longum]
MSIQIATRVSDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDET
R

Download         Length: 246 bp

>AT47843 NZ_CP008885:c987012-986767 [Bifidobacterium longum]
ATGAGCATACAGATTGCCACGCGAGTTAGTGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCAGGCAGCTGGGTACCAC
CCCGGCCGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAA
ATGACGTGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACG
AGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4KDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A087BFX1

References