Detailed information of TA system TA047765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 3731546..3732051
• Replicon: chromosome
• Accession: NZ_CP008863
• Organism: Pseudomonas aeruginosa strain M37351

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: HW03_RS17185
• Protein ID: WP_003083773.1
• Coordinates: 3731546..3731827 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0H2ZJU8
• Locus tag: HW03_RS17190
• Protein ID: WP_003137009.1
• Coordinates: 3731824..3732051 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HW03_RS17160	3726797..3728146	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
HW03_RS17165	3728195..3728881	+	687	WP_003083762.1	FadR family transcriptional regulator	-
HW03_RS17170	3728982..3729716	+	735	WP_003110658.1	GntR family transcriptional regulator	-
HW03_RS17175	3729920..3730306	+	387	WP_003083767.1	aegerolysin family protein	-
HW03_RS17180	3730338..3731246	-	909	WP_003083769.1	LysR family transcriptional regulator	-
HW03_RS17185	3731546..3731827	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
HW03_RS17190	3731824..3732051	-	228	WP_003137009.1	CopG family ribbon-helix-helix protein	Antitoxin
HW03_RS17195	3732227..3732850	-	624	WP_003137011.1	hypothetical protein	-
HW03_RS17200	3732951..3733451	+	501	WP_003137013.1	LEA type 2 family protein	-
HW03_RS17205	3733523..3733864	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
HW03_RS17210	3733946..3735373	-	1428	WP_003137015.1	GABA permease	-
HW03_RS17215	3735542..3737035	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T47765 WP_003083773.1 NZ_CP008863:c3731827-3731546 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T47765 NZ_CP008863:c3731827-3731546 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8526.56 Da
• Isoelectric Point: 5.5740

>AT47765 WP_003137009.1 NZ_CP008863:c3732051-3731824 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT47765 NZ_CP008863:c3732051-3731824 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAGCACGCCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A0H2ZJU8