Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5803558..5804144 Replicon chromosome
Accession NZ_CP008861
Organism Pseudomonas aeruginosa strain H47921

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag HW05_RS26700 Protein ID WP_003120987.1
Coordinates 5803558..5803857 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HW05_RS26705 Protein ID WP_003448662.1
Coordinates 5803854..5804144 (+) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW05_RS26680 5798671..5799204 - 534 WP_003099760.1 type IV pilus biogenesis protein PilP -
HW05_RS26685 5799194..5800519 - 1326 WP_003099758.1 type 4b pilus protein PilO2 -
HW05_RS26690 5800523..5802232 - 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
HW05_RS26695 5802232..5803356 - 1125 WP_012076859.1 TcpQ domain-containing protein -
HW05_RS26700 5803558..5803857 + 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW05_RS26705 5803854..5804144 + 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
HW05_RS26710 5804215..5804559 - 345 WP_016851612.1 hypothetical protein -
HW05_RS26715 5804700..5806676 - 1977 WP_016851611.1 DEAD/DEAH box helicase -
HW05_RS26720 5806673..5808562 - 1890 WP_016851610.1 hypothetical protein -
HW05_RS26725 5808784..5808993 - 210 WP_003105733.1 cold-shock protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5739208..5820841 81633


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T47754 WP_003120987.1 NZ_CP008861:5803558-5803857 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

>T47754 NZ_CP008861:5803558-5803857 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT47754 WP_003448662.1 NZ_CP008861:5803854-5804144 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp

>AT47754 NZ_CP008861:5803854-5804144 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCTACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGAGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB G8CP73


Antitoxin

Source ID Structure

References