47198

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2967180..2967828 Replicon chromosome
Accession NZ_CP007809
Organism Mycobacterium tuberculosis strain KIT87190

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag ER17_RS14005 Protein ID WP_003899414.1
Coordinates 2967180..2967503 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag ER17_RS14010 Protein ID WP_003899415.1
Coordinates 2967583..2967828 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER17_RS13975 2962503..2963501 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
ER17_RS13980 2963515..2963979 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
ER17_RS13985 2963967..2964218 + 252 WP_003908028.1 hypothetical protein -
ER17_RS13990 2964389..2965828 - 1440 WP_003901443.1 phage major capsid protein -
ER17_RS13995 2965836..2966369 - 534 WP_003899412.1 HK97 family phage prohead protease -
ER17_RS21655 2966522..2967013 - 492 WP_003900541.1 phage terminase small subunit P27 family -
ER17_RS14005 2967180..2967503 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
ER17_RS14010 2967583..2967828 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
ER17_RS14015 2967825..2969252 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
ER17_RS14020 2969254..2969646 - 393 WP_003899417.1 DUF2742 domain-containing protein -
ER17_RS14025 2969643..2969903 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
ER17_RS14030 2969920..2970282 - 363 WP_003900543.1 hypothetical protein -
ER17_RS14035 2970285..2971412 - 1128 WP_003899420.1 site-specific integrase -
ER17_RS14040 2971557..2971784 - 228 WP_003899421.1 hypothetical protein -
ER17_RS21660 2971781..2972170 - 390 WP_003899422.1 hypothetical protein -
ER17_RS14045 2972076..2972348 + 273 WP_003900544.1 hypothetical protein -
ER17_RS14050 2972447..2972680 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2962503..2971412 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(7-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T47198 WP_003899414.1 NZ_CP007809:c2967503-2967180 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T47198 NZ_CP007809:c2967503-2967180 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT47198 WP_003899415.1 NZ_CP007809:c2967828-2967583 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT47198 NZ_CP007809:c2967828-2967583 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References