Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15499..15757 Replicon chromosome
Accession NZ_CP007799
Organism Escherichia coli Nissle 1917

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag ECOLIN_RS00085 Protein ID WP_000809168.1
Coordinates 15499..15651 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15700..15757 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLIN_RS00065 (ECOLIN_00055) 10744..11457 - 714 WP_001102391.1 acidic protein MsyB -
ECOLIN_RS00070 (ECOLIN_00060) 11483..11887 - 405 WP_000843687.1 DUF2541 family protein -
ECOLIN_RS00075 (ECOLIN_00065) 12259..14175 + 1917 WP_000516135.1 molecular chaperone DnaK -
ECOLIN_RS00080 (ECOLIN_00070) 14264..15394 + 1131 WP_001118465.1 molecular chaperone DnaJ -
ECOLIN_RS00085 (ECOLIN_00075) 15499..15651 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15700..15757 + 58 - - Antitoxin
ECOLIN_RS00090 (ECOLIN_00080) 16266..17027 + 762 WP_001274832.1 hypothetical protein -
ECOLIN_RS00095 (ECOLIN_00085) 17047..18540 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
ECOLIN_RS00100 (ECOLIN_00090) 18669..19928 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T47024 WP_000809168.1 NZ_CP007799:c15651-15499 [Escherichia coli Nissle 1917]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T47024 NZ_CP007799:c15651-15499 [Escherichia coli Nissle 1917]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT47024 NZ_CP007799:15700-15757 [Escherichia coli Nissle 1917]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References