Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2897119..2898857 Replicon chromosome
Accession NZ_CP007784
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name doc Uniprot ID A0A088UCR9
Locus tag DM39_RS33890 Protein ID WP_040131501.1
Coordinates 2897119..2898006 (+) Length 296 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A132F6R9
Locus tag DM39_RS33895 Protein ID WP_040131503.1
Coordinates 2898003..2898857 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS33860 2892520..2893599 - 1080 WP_040131495.1 porin -
DM39_RS33865 2894034..2894351 + 318 WP_006396774.1 non-heme iron oxygenase ferredoxin subunit -
DM39_RS33870 2894353..2894664 + 312 WP_009692515.1 hypothetical protein -
DM39_RS33875 2894711..2895781 + 1071 WP_009692516.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DM39_RS33880 2895774..2896544 + 771 WP_040131498.1 SDR family oxidoreductase -
DM39_RS33885 2896573..2897100 + 528 WP_009692519.1 cupin domain-containing protein -
DM39_RS33890 2897119..2898006 + 888 WP_040131501.1 alpha/beta fold hydrolase Toxin
DM39_RS33895 2898003..2898857 + 855 WP_040131503.1 IclR family transcriptional regulator Antitoxin
DM39_RS33900 2898854..2899651 + 798 WP_040131505.1 SDR family oxidoreductase -
DM39_RS33905 2899644..2901311 + 1668 WP_040131507.1 thiamine pyrophosphate-binding protein -
DM39_RS33910 2901304..2902131 + 828 WP_040131509.1 aspartate dehydrogenase -
DM39_RS33915 2902209..2903699 + 1491 WP_040131511.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(48-276)

Antitoxin

Transcription regulator IclR, C-terminal

(142-265)


Sequences

Toxin        


Download         Length: 296 a.a.        Molecular weight: 30368.60 Da        Isoelectric Point: 7.9595

>T47014 WP_040131501.1 NZ_CP007784:2897119-2898006 [Burkholderia cenocepacia]
MSVVEKRERDRFATLLGQFPEQRCAAGAAGTIGYREAGAQQAGRTLPVVLLHGIGSGAASWVCQLDALGASRRVLAWDAP
GYGASTPVNGASPAAADYAASLNAWLDALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLISPAGGYGSAPAETRESR
RDARLAMLAELGPEGLAAQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVGAND
AITPPAACERIAAAARVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDRQWGLA

Download         Length: 888 bp

>T47014 NZ_CP007784:2897119-2898006 [Burkholderia cenocepacia]
ATGAGTGTCGTCGAAAAACGTGAGCGCGACCGGTTCGCGACGCTGCTCGGGCAGTTTCCCGAGCAGCGCTGCGCGGCCGG
TGCGGCGGGCACGATCGGATACCGCGAGGCCGGCGCGCAACAGGCCGGCCGCACGCTGCCCGTCGTGCTGCTGCACGGGA
TCGGCTCGGGCGCCGCGTCGTGGGTGTGCCAGCTCGATGCGCTCGGCGCGTCGCGCCGGGTGCTCGCGTGGGATGCGCCC
GGCTACGGCGCATCGACGCCCGTGAACGGCGCGTCGCCGGCCGCCGCCGATTACGCGGCGTCGCTGAACGCGTGGCTCGA
CGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCGTCGCGGGCGGCCTGGCCCGCGTGATGC
CCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCTGCGGGCGGCTACGGCAGTGCGCCCGCCGAAACGCGCGAATCGCGC
CGCGACGCGCGCCTCGCGATGCTCGCGGAGCTCGGCCCGGAAGGGCTCGCAGCGCAGCGCAGCGGCAACATGCTGTCGGG
CTTCGCGAGCGAGGATGCACGTGCATGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCGCAGGCCACGC
ACCTGCTCGCGAACGCGGATCTCGCGACCGATCTCGCCGGCTTTCGCGGCCGCACGGCGGTGGCGGTCGGCGCGAACGAC
GCGATCACGCCGCCCGCCGCATGCGAGCGGATCGCCGCGGCCGCGCGGGTCGGGCTGCAGGTGATTCCGCAGGCCGGCCA
CGCCGGCTACGTGGAAGCGCCGGCCGTCTATTCCGCGCTGATCGACGCGTTCTGCCGTCAGTGCGACCGGCAGTGGGGGC
TGGCATGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31259.86 Da        Isoelectric Point: 6.6572

>AT47014 WP_040131503.1 NZ_CP007784:2898003-2898857 [Burkholderia cenocepacia]
MSEPLQKEVEGAKSEANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVLESLRDATGFTTHIVIRDGRDVVFVAKAQSQAAVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLKELRALYPEGVLPRMTSATPETVEALYEVIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDDALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT47014 NZ_CP007784:2898003-2898857 [Burkholderia cenocepacia]
ATGAGCGAACCGCTGCAAAAGGAAGTGGAAGGCGCGAAGAGCGAGGCCAACTACGTGGTGCCGGGCCTCGAGCGCGGCTT
GCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAACTGTCGAAGCGGCTCGGGATTCCGCGCA
CGACGGTGTTCCGCCTGCTGCAGACGCTGGAATCGCTCGGCTTTCTCGAACGTGCGGACAAGGATCGCAACTACAAGCTC
GGCATCGCGGTGCTGCGACTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGCTCGAAAG
CCTGCGCGACGCGACCGGCTTCACGACGCATATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGCAGA
GCCAGGCGGCGGTGTTCAGCTCGATTCGCGTGAACGTCGGCACGCGGCTGCCTGCGCATGCCACGACGCACGGCCACGTG
CTGATGGGCGACCTGTCGCTGAAGGAACTGCGCGCGCTGTATCCGGAAGGCGTGCTGCCGCGGATGACGAGCGCGACGCC
GGAAACGGTCGAGGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCGAGC
GCGGCATCTCGGTCGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCATGCATCACGGTGACGGTGCCGCGT
CCGGAGATCGACGACGCGCTGATCGCGGACGGATTGATCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGAAGGCT
CAATTATCGCTCGGATGACGAGCACACGTTTCTCAAGGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A088UCR9

Antitoxin

Source ID Structure
AlphaFold DB A0A132F6R9

References