Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2719782..2720473 Replicon chromosome
Accession NZ_CP007784
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A088UGM9
Locus tag DM39_RS33130 Protein ID WP_040131295.1
Coordinates 2720018..2720473 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132F1C7
Locus tag DM39_RS33125 Protein ID WP_012216644.1
Coordinates 2719782..2720021 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS33100 2715005..2715400 - 396 WP_009688937.1 type II toxin-antitoxin system VapC family toxin -
DM39_RS33105 2715397..2715636 - 240 WP_040131292.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DM39_RS33110 2715793..2716476 - 684 WP_009688936.1 Fe2+-dependent dioxygenase -
DM39_RS33115 2716473..2717228 - 756 WP_040131293.1 sel1 repeat family protein -
DM39_RS33120 2717232..2719478 - 2247 WP_040131294.1 TonB-dependent siderophore receptor -
DM39_RS33125 2719782..2720021 + 240 WP_012216644.1 Arc family DNA-binding protein Antitoxin
DM39_RS33130 2720018..2720473 + 456 WP_040131295.1 type II toxin-antitoxin system VapC family toxin Toxin
DM39_RS33135 2720573..2721868 - 1296 WP_009688931.1 aspartate carbamoyltransferase -
DM39_RS33140 2722103..2722237 + 135 WP_009688930.1 entericidin A/B family lipoprotein -
DM39_RS33145 2722334..2722903 - 570 WP_040131298.1 hypothetical protein -
DM39_RS33150 2723053..2724000 - 948 WP_040132084.1 DMT family transporter -
DM39_RS33155 2724056..2724850 - 795 WP_040131300.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16242.57 Da        Isoelectric Point: 8.6578

>T47013 WP_040131295.1 NZ_CP007784:2720018-2720473 [Burkholderia cenocepacia]
MILVDTNVISEPLRREPSSAVIEWLDAQNVETLFLAAISLAEMRFGVAALPAGRRRDWLQQSIEHRVVPMFRGRILPFDD
AASQAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGARGRPGIASK

Download         Length: 456 bp

>T47013 NZ_CP007784:2720018-2720473 [Burkholderia cenocepacia]
ATGATCCTTGTTGATACGAACGTCATTTCCGAACCGCTGCGGCGCGAGCCGAGCTCGGCCGTGATCGAATGGCTCGACGC
GCAGAACGTCGAGACGCTGTTCCTGGCCGCGATCAGCCTCGCCGAAATGCGCTTCGGTGTCGCGGCGCTGCCGGCAGGAC
GCCGGCGGGACTGGCTGCAGCAAAGCATCGAGCATCGTGTCGTGCCGATGTTTCGCGGCCGCATTCTGCCGTTCGACGAT
GCCGCGAGCCAGGCCTATGCGCGCATTCGCGCGCACGCCCGTGCCGGCGGCAACGCGATCGCGCCCGCCGACGGCTACAT
TGCCGCGACGGCCGAGGCGAATGGCCTGATCGTCGCGACGCGCGACGTCGCGCCGTTCGAGGCCGCGGGCCTGCGCGTGA
TCGATCCGTGGGCGTCGCAGGGCGCGCGAGGGCGCCCGGGCATCGCGTCGAAATGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8716.94 Da        Isoelectric Point: 5.1133

>AT47013 WP_012216644.1 NZ_CP007784:2719782-2720021 [Burkholderia cenocepacia]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT47013 NZ_CP007784:2719782-2720021 [Burkholderia cenocepacia]
ATGCCTGTGATTACCGTTCGAAATTTGCCGGATGAAGTGCATCGCGCCCTTCGGGTCCGCGCGGCGCTGCATGGGCGCAG
TACCGAGGCAGAGGTGCGCGACATCCTCGAGCAGGCCGTGCTGTCGGAAGGACGCGTCAAGCTGGGAACCTTGCTGGCGG
AAATCGGGCGGGAGGCAGGCGGTGTCGATCTCGACATCCAGCGTGACAAGACGCCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A088UGM9

Antitoxin

Source ID Structure
AlphaFold DB A0A132F1C7

References