Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1611795..1612452 Replicon chromosome
Accession NZ_CP007784
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name higB Uniprot ID A0A132F219
Locus tag DM39_RS28215 Protein ID WP_040130600.1
Coordinates 1612120..1612452 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A132F3F8
Locus tag DM39_RS28210 Protein ID WP_009692860.1
Coordinates 1611795..1612127 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS28185 1607621..1608628 + 1008 WP_040130597.1 hypothetical protein -
DM39_RS28190 1608790..1609599 + 810 WP_040130598.1 TlpA family protein disulfide reductase -
DM39_RS28195 1609633..1610883 - 1251 Protein_1433 DHA2 family efflux MFS transporter permease subunit -
DM39_RS28200 1610777..1611205 + 429 WP_080293072.1 SymE family type I addiction module toxin -
DM39_RS28205 1611202..1611540 + 339 WP_040130599.1 XRE family transcriptional regulator -
DM39_RS28210 1611795..1612127 - 333 WP_009692860.1 helix-turn-helix domain-containing protein Antitoxin
DM39_RS28215 1612120..1612452 - 333 WP_040130600.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM39_RS28220 1612764..1613531 - 768 WP_040130601.1 peptidyl-prolyl cis-trans isomerase -
DM39_RS28225 1613941..1614105 - 165 Protein_1439 glycosyl transferase -
DM39_RS38530 1614365..1614523 + 159 WP_158377456.1 hypothetical protein -
DM39_RS28230 1615036..1616427 + 1392 WP_040130602.1 undecaprenyl-phosphate glucose phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(18-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(52-105)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12879.93 Da        Isoelectric Point: 9.7734

>T47011 WP_040130600.1 NZ_CP007784:c1612452-1612120 [Burkholderia cenocepacia]
MKNWTILYYNERVKRDVFALPRGILAGYLRLIEMMEEHGADLRMPHSRAMGDGLFELRPRGREGVGRVFYCSQVGYELVI
LHSFVKKTQETPGDELRIAHRRMKEVRNDG

Download         Length: 333 bp

>T47011 NZ_CP007784:c1612452-1612120 [Burkholderia cenocepacia]
ATGAAGAACTGGACGATCCTGTACTACAACGAACGTGTGAAGCGCGACGTATTTGCTTTGCCCAGGGGCATTCTCGCGGG
CTACCTTCGTCTGATCGAAATGATGGAGGAACACGGCGCGGACCTACGGATGCCGCATTCGCGTGCGATGGGAGACGGAT
TGTTCGAATTGCGCCCGAGAGGCCGTGAAGGTGTCGGGCGCGTGTTTTATTGCTCGCAGGTGGGATATGAACTCGTCATC
CTGCATTCCTTCGTCAAGAAGACGCAGGAAACGCCTGGCGACGAGCTACGTATTGCCCACCGGCGGATGAAGGAGGTTCG
CAACGATGGCTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11927.59 Da        Isoelectric Point: 9.8897

>AT47011 WP_009692860.1 NZ_CP007784:c1612127-1611795 [Burkholderia cenocepacia]
MAKIRSARAGKDRYAPVRHTAEDTARLLADPTLKAEYDALEEEFTALRALLDARKEAGLTQAQVAERMGTTTSAVSRLEA
SLSSEKHSPSFATLRKYAAACGKKLVISFA

Download         Length: 333 bp

>AT47011 NZ_CP007784:c1612127-1611795 [Burkholderia cenocepacia]
ATGGCTAAGATCCGCTCGGCACGCGCCGGGAAGGACCGGTATGCACCGGTCCGACACACTGCCGAAGACACCGCCCGTCT
GCTCGCCGACCCCACACTCAAGGCGGAATACGACGCGCTGGAAGAGGAATTCACCGCGCTTCGAGCGCTGCTGGATGCGC
GTAAAGAGGCAGGCCTGACGCAGGCTCAGGTCGCCGAGCGAATGGGAACCACGACATCTGCCGTATCCAGGCTCGAGGCC
TCGTTGTCGAGCGAAAAGCACTCGCCGTCGTTTGCGACGTTGCGCAAGTATGCCGCGGCGTGCGGGAAGAAGCTCGTCAT
TTCGTTTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132F219

Antitoxin

Source ID Structure
AlphaFold DB A0A132F3F8

References