Detailed information of TA system TA046818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1464459..1465056
• Replicon: chromosome
• Accession: NZ_CP007667
• Organism: Neisseria meningitidis strain B6116/77

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0Y6JZK6
• Locus tag: B6116_RS07725
• Protein ID: WP_002242826.1
• Coordinates: 1464778..1465056 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: B6116_RS07720
• Protein ID: WP_002221020.1
• Coordinates: 1464459..1464770 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B6116_RS13980	1460384..1460548	+	165	WP_002224559.1	baseplate J/gp47 family protein	-
B6116_RS07705	1460548..1461159	+	612	WP_002226380.1	baseplate J/gp47 family protein	-
B6116_RS07710	1461156..1461716	+	561	WP_002213590.1	YmfQ family protein	-
B6116_RS07715	1461727..1463703	+	1977	WP_002226379.1	pyocin knob domain-containing protein	-
B6116_RS07720	1464459..1464770	-	312	WP_002221020.1	HigA family addiction module antidote protein	Antitoxin
B6116_RS07725	1464778..1465056	-	279	WP_002242826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
B6116_RS07730	1465141..1465746	+	606	WP_002219301.1	hypothetical protein	-
B6116_RS07735	1465725..1466021	+	297	WP_002221017.1	hypothetical protein	-
B6116_RS07740	1466018..1466227	+	210	WP_002222487.1	hypothetical protein	-
B6116_RS07745	1466337..1467479	-	1143	WP_002221015.1	ABC transporter ATP-binding protein/permease	-
B6116_RS07755	1467922..1468569	-	648	WP_002217218.1	DUF799 domain-containing protein	-
B6116_RS07760	1468566..1468934	-	369	WP_002219297.1	DUF4810 domain-containing protein	-
B6116_RS07765	1468944..1469615	-	672	WP_002239761.1	CsgG/HfaB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1452505..1466021	13516
	-	flank	IS/Tn	-	-	1459354..1460319	965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (3-80)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10237.66 Da
• Isoelectric Point: 10.0980

>T46818 WP_002242826.1 NZ_CP007667:c1465056-1464778 [Neisseria meningitidis]
MIVSFKHKGLERFFKTGSLSGIQAGHSVKLNLLLTALNAAQTPSDMAVPSWNLHPLKGSLSGHWAVKVNGNWRLTFRFND
GNAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T46818 NZ_CP007667:c1465056-1464778 [Neisseria meningitidis]
ATGATTGTTTCTTTCAAACACAAAGGGCTTGAACGCTTTTTTAAAACAGGCTCGCTATCGGGCATCCAAGCCGGGCATTC
CGTCAAACTGAATCTGCTTCTAACCGCGCTGAATGCCGCGCAAACGCCTTCGGATATGGCTGTGCCGAGTTGGAATCTTC
ATCCCCTCAAGGGCAGTTTGTCGGGACATTGGGCGGTTAAAGTCAACGGAAATTGGCGTTTGACTTTTCGTTTCAACGAC
GGCAATGCCGAAGTTGTCGATTATCAGGATTATCACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 11476.32 Da
• Isoelectric Point: 10.5523

>AT46818 WP_002221020.1 NZ_CP007667:c1464770-1464459 [Neisseria meningitidis]
MKMHNPAHPGLVLKEYINGASITDIAKRLGVSRVALSRIVNAQSSITPEMAVRLSQLLNTSPDFWLNMQAGYDLWQIRQR
KTFDIAPLFPEPPLSSMQTGARA

Nucleotide

• Length: 312 bp

>AT46818 NZ_CP007667:c1464770-1464459 [Neisseria meningitidis]
ATGAAAATGCACAATCCTGCCCACCCGGGCCTTGTTTTAAAAGAGTATATTAACGGTGCAAGCATTACCGATATAGCGAA
ACGCCTGGGTGTCAGCCGGGTTGCCTTATCGCGCATTGTCAACGCCCAATCTTCGATTACGCCCGAGATGGCGGTTCGTT
TAAGCCAACTGCTCAATACTTCGCCTGATTTTTGGCTGAATATGCAGGCCGGTTATGATTTGTGGCAAATCAGGCAACGC
AAAACTTTTGATATTGCGCCCTTATTTCCCGAACCGCCTTTGTCTTCGATGCAAACAGGTGCAAGGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0Y6JZK6