Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4831146..4831981 | Replicon | chromosome |
| Accession | NZ_CP007594 | ||
| Organism | Escherichia coli strain SEC470 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | E3PD61 |
| Locus tag | DP32_RS24230 | Protein ID | WP_001094449.1 |
| Coordinates | 4831146..4831523 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | E3PD62 |
| Locus tag | DP32_RS24235 | Protein ID | WP_001280916.1 |
| Coordinates | 4831613..4831981 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DP32_RS24200 | 4826929..4827626 | - | 698 | Protein_4582 | IS1 family transposase | - |
| DP32_RS24210 | 4828191..4829726 | - | 1536 | WP_000492893.1 | EAL domain-containing protein | - |
| DP32_RS24215 | 4829797..4830642 | - | 846 | WP_001290175.1 | DUF4942 domain-containing protein | - |
| DP32_RS29420 | 4830727..4830924 | - | 198 | WP_087891818.1 | DUF957 domain-containing protein | - |
| DP32_RS29425 | 4831000..4831149 | - | 150 | Protein_4586 | hypothetical protein | - |
| DP32_RS24230 | 4831146..4831523 | - | 378 | WP_001094449.1 | TA system toxin CbtA family protein | Toxin |
| DP32_RS24235 | 4831613..4831981 | - | 369 | WP_001280916.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| DP32_RS24240 | 4831997..4832641 | - | 645 | WP_000086751.1 | hypothetical protein | - |
| DP32_RS24245 | 4832660..4832881 | - | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
| DP32_RS24250 | 4832944..4833420 | - | 477 | WP_001186781.1 | RadC family protein | - |
| DP32_RS24255 | 4833435..4833908 | - | 474 | WP_000855079.1 | antirestriction protein | - |
| DP32_RS24260 | 4834210..4835028 | - | 819 | WP_001234607.1 | DUF945 domain-containing protein | - |
| DP32_RS28120 | 4835128..4835361 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| DP32_RS24270 | 4835419..4836096 | + | 678 | WP_001339397.1 | IS66 family insertion sequence hypothetical protein | - |
| DP32_RS24275 | 4836096..4836443 | + | 348 | WP_000624622.1 | IS66 family insertion sequence element accessory protein TnpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 4826929..4827306 | 377 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14162.00 Da Isoelectric Point: 6.6312
>T46712 WP_001094449.1 NZ_CP007594:c4831523-4831146 [Escherichia coli]
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SSCTHSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ
MNTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SSCTHSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ
Download Length: 378 bp
>T46712 NZ_CP007594:c4831523-4831146 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTAAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCAGCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACGCTAAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCAGCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCCCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13790.68 Da Isoelectric Point: 5.8808
>AT46712 WP_001280916.1 NZ_CP007594:c4831981-4831613 [Escherichia coli]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLICEADPLGSCGYVYLAVYPTPEMKN
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLICEADPLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT46712 NZ_CP007594:c4831981-4831613 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGATCTGTGAAGCCGACCCCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGATCTGTGAAGCCGACCCCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|