Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1819662..1820174 Replicon chromosome
Accession NZ_CP007593
Organism Streptococcus pneumoniae strain NT_110_58

Toxin (Protein)


Gene name yoeB Uniprot ID A0A064C0G5
Locus tag spnnt_RS09160 Protein ID WP_016398855.1
Coordinates 1819662..1819916 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0B4ZN65
Locus tag spnnt_RS09165 Protein ID WP_016398854.1
Coordinates 1819920..1820174 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
spnnt_RS11875 1815388..1816071 - 684 WP_016398858.1 hypothetical protein -
spnnt_RS11880 1816074..1817345 - 1272 WP_016398857.1 restriction endonuclease subunit S -
spnnt_RS09155 1817338..1819446 - 2109 WP_016398856.1 type I restriction-modification system subunit M -
spnnt_RS09160 1819662..1819916 - 255 WP_016398855.1 Txe/YoeB family addiction module toxin Toxin
spnnt_RS09165 1819920..1820174 - 255 WP_016398854.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
spnnt_RS09170 1820306..1821403 - 1098 WP_016398853.1 nucleotidyltransferase -
spnnt_RS09175 1821413..1822159 - 747 WP_075588448.1 class I SAM-dependent methyltransferase -
spnnt_RS09180 1822372..1822722 - 351 WP_016398852.1 ribosome silencing factor -
spnnt_RS09185 1822723..1823316 - 594 WP_016398851.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK -
spnnt_RS09190 1823316..1823945 - 630 WP_016398850.1 nicotinate-nucleotide adenylyltransferase -
spnnt_RS09195 1823997..1824308 - 312 WP_000060163.1 ribosome assembly RNA-binding protein YhbY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10037.43 Da        Isoelectric Point: 6.9739

>T46687 WP_016398855.1 NZ_CP007593:c1819916-1819662 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQTQDKKTLKRINKLIKDIQSDSFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSIAFLSF
KDHY

Download         Length: 255 bp

>T46687 NZ_CP007593:c1819916-1819662 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCGTGGGCAGATTATTGCTACTGGCAAACTCAGGATAAGAAAACACTAAAAAGAAT
CAATAAACTAATTAAGGATATTCAAAGTGATTCATTTACAGGAATAGGAAAACCAGAACCACTCAAGTATGACTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCATCGCTTTTTTGTCCTTC
AAAGATCACTACTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9734.05 Da        Isoelectric Point: 4.8430

>AT46687 WP_016398854.1 NZ_CP007593:c1820174-1819920 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIVQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT46687 NZ_CP007593:c1820174-1819920 [Streptococcus pneumoniae]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTAAAAGACTACATGAAGAAGGTCAATGATGAATTTGAGCCTTT
AACGGTGGTTAATAAAAATCCAGATGAGGACATTGTAGTTCTTTCAAAGAGCGAATGGGACAGTATTCAGGAAACCCTGA
GAATCGTTCAAAATAAGGAGTTATCAGACAAGGTTTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAAGTCCAT
GTTATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A064C0G5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B4ZN65

References