Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3774115..3774754 Replicon chromosome
Accession NZ_CP007557
Organism Citrobacter freundii CFNIH1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CFNIH1_RS17935 Protein ID WP_038640738.1
Coordinates 3774578..3774754 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CFNIH1_RS17930 Protein ID WP_087856629.1
Coordinates 3774115..3774531 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFNIH1_RS17910 3769160..3770104 - 945 WP_038640728.1 ABC transporter permease -
CFNIH1_RS17915 3770105..3771121 - 1017 WP_038640730.1 ABC transporter ATP-binding protein -
CFNIH1_RS17920 3771138..3772283 - 1146 WP_038640732.1 ABC transporter substrate-binding protein -
CFNIH1_RS17925 3772613..3774022 - 1410 WP_038640734.1 PLP-dependent aminotransferase family protein -
CFNIH1_RS17930 3774115..3774531 - 417 WP_087856629.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CFNIH1_RS17935 3774578..3774754 - 177 WP_038640738.1 type II toxin-antitoxin system HicA family toxin Toxin
CFNIH1_RS17940 3775019..3776422 + 1404 WP_038640740.1 cytochrome ubiquinol oxidase subunit I -
CFNIH1_RS17945 3776422..3777432 + 1011 WP_038640742.1 cytochrome d ubiquinol oxidase subunit II -
CFNIH1_RS26950 3777432..3777557 + 126 WP_064507023.1 DUF2474 domain-containing protein -
CFNIH1_RS17950 3777747..3777977 + 231 WP_038640744.1 DUF2554 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-56)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6809.87 Da        Isoelectric Point: 11.6208

>T46627 WP_038640738.1 NZ_CP007557:c3774754-3774578 [Citrobacter freundii CFNIH1]
VKQSEFRRWLESQGVKVTNGSNHLKLRYQGRRSVMPRHPVDEIKEALRKAIQKQPGLQ

Download         Length: 177 bp

>T46627 NZ_CP007557:c3774754-3774578 [Citrobacter freundii CFNIH1]
GTGAAGCAAAGTGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTTAAAGTTACAAACGGCTCAAATCATCTGAAGTTGAG
GTATCAGGGAAGGCGTAGCGTTATGCCCAGGCATCCTGTTGATGAGATAAAAGAGGCCCTGCGAAAAGCGATCCAAAAGC
AGCCTGGCTTACAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.35 Da        Isoelectric Point: 4.5468

>AT46627 WP_087856629.1 NZ_CP007557:c3774531-3774115 [Citrobacter freundii CFNIH1]
MRYPVNLIPAVEGGFMVSFPDIPEALTQGETRHDALQAAQAALVTAFEFYFDDNEPIPLPSAVVAGADYVEIPLSVASKV
LLLNAFLESNITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp

>AT46627 NZ_CP007557:c3774531-3774115 [Citrobacter freundii CFNIH1]
ATGCGTTATCCCGTTAATCTAATACCCGCCGTGGAAGGTGGGTTCATGGTGTCTTTTCCGGATATTCCTGAAGCATTGAC
TCAGGGAGAAACTCGCCATGATGCTTTGCAGGCTGCGCAGGCCGCATTGGTCACCGCTTTTGAATTCTATTTCGACGATA
ACGAACCGATTCCTTTGCCTTCAGCGGTTGTCGCTGGCGCTGACTATGTGGAAATACCACTGAGCGTTGCGTCTAAGGTT
CTGTTGTTAAATGCCTTCCTTGAATCGAATATTACCCAGCAGGAGTTGGCAAACAGGATCGGCAGGCCTAAGCAGGAAAT
CACCCGTTTATTCGATTTAAAGCACGCGACAAAAATTGATGCTGTGCAGATAGCTGCCCGCGCTTTAGGAAAAGAACTGT
CGGTAACGATGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References