Detailed information of TA system TA046591

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2023968..2024547
• Replicon: chromosome
• Accession: NZ_CP007539
• Organism: Staphylococcus aureus strain FDAARGOS_5

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: X998_RS10760
• Protein ID: WP_001025401.1
• Coordinates: 2024302..2024547 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2023968..2024333 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
X998_RS10690	2018968..2019768	-	801	WP_000504976.1	phage replisome organizer N-terminal domain-containing protein	-
X998_RS10695	2019740..2020435	-	696	WP_001124444.1	hypothetical protein	-
X998_RS10700	2020449..2020868	-	420	WP_000934777.1	single-stranded DNA-binding protein	-
X998_RS10705	2020868..2021491	-	624	WP_000139722.1	DUF1071 domain-containing protein	-
X998_RS10710	2021484..2021705	-	222	WP_000815401.1	DUF2483 family protein	-
X998_RS10715	2021715..2021975	-	261	WP_001556704.1	DUF1108 family protein	-
X998_RS10720	2021980..2022297	-	318	WP_001097093.1	hypothetical protein	-
X998_RS10725	2022387..2022548	-	162	WP_001285962.1	DUF1270 domain-containing protein	-
X998_RS10730	2022561..2022824	-	264	WP_001124196.1	helix-turn-helix domain-containing protein	-
X998_RS10735	2022879..2023130	+	252	WP_000801109.1	hypothetical protein	-
X998_RS10740	2023108..2023299	-	192	WP_000389907.1	hypothetical protein	-
X998_RS10745	2023347..2023727	+	381	WP_000773060.1	DUF2513 domain-containing protein	-
X998_RS10750	2023714..2023911	-	198	WP_031903992.1	hypothetical protein	-
X998_RS10755	2023968..2024333	+	366	WP_001128433.1	hypothetical protein	Antitoxin
X998_RS10760	2024302..2024547	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
X998_RS10765	2024587..2024811	-	225	WP_000187184.1	hypothetical protein	-
X998_RS10770	2024812..2025603	-	792	WP_001148570.1	phage antirepressor KilAC domain-containing protein	-
X998_RS10775	2025760..2026068	-	309	WP_001153965.1	hypothetical protein	-
X998_RS10780	2026083..2026301	-	219	WP_001198674.1	helix-turn-helix domain-containing protein	-
X998_RS10785	2026443..2027162	+	720	WP_000358220.1	XRE family transcriptional regulator	-
X998_RS10790	2027362..2027544	+	183	WP_000705240.1	hypothetical protein	-
X998_RS10795	2027622..2028335	+	714	WP_001582614.1	type II toxin-antitoxin system PemK/MazF family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	geh	1987003..2038974	51971

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T46591 WP_001025401.1 NZ_CP007539:c2024547-2024302 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T46591 NZ_CP007539:c2024547-2024302 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT46591 NZ_CP007539:2023968-2024333 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin