Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 596490..596976 Replicon chromosome
Accession NZ_CP007497
Organism Streptococcus suis strain ZY05719 isolate diseased pig

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag ZY05719_RS03015 Protein ID WP_011922754.1
Coordinates 596707..596976 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag ZY05719_RS03010 Protein ID WP_002938604.1
Coordinates 596490..596717 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ZY05719_RS02980 (ZY05719_02965) 591533..591982 - 450 WP_009909619.1 MarR family transcriptional regulator -
ZY05719_RS10455 592276..593123 + 848 WP_087892711.1 IS630 family transposase -
ZY05719_RS02995 (ZY05719_02980) 593182..593679 + 498 WP_011922751.1 DUF5590 domain-containing protein -
ZY05719_RS03000 (ZY05719_02985) 593676..594857 + 1182 WP_011922154.1 pyridoxal phosphate-dependent aminotransferase -
ZY05719_RS03005 (ZY05719_02990) 594872..596218 + 1347 WP_011922752.1 asparagine--tRNA ligase -
ZY05719_RS03010 (ZY05719_02995) 596490..596717 + 228 WP_002938604.1 hypothetical protein Antitoxin
ZY05719_RS03015 (ZY05719_03000) 596707..596976 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ZY05719_RS03020 (ZY05719_03005) 597382..598701 + 1320 WP_012775027.1 MATE family efflux transporter -
ZY05719_RS03025 (ZY05719_03010) 598752..599129 + 378 WP_002937263.1 RidA family protein -
ZY05719_RS03030 (ZY05719_03015) 599151..600038 + 888 WP_011922160.1 RNase adapter RapZ -
ZY05719_RS03035 (ZY05719_03020) 600035..601009 + 975 WP_002937257.1 YvcK family protein -
ZY05719_RS03040 (ZY05719_03025) 601006..601923 + 918 WP_002937252.1 DNA-binding protein WhiA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T46532 WP_011922754.1 NZ_CP007497:596707-596976 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

>T46532 NZ_CP007497:596707-596976 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT46532 WP_002938604.1 NZ_CP007497:596490-596717 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp

>AT46532 NZ_CP007497:596490-596717 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References